نتایج جستجو برای: intraperitoneal bupivacaine

تعداد نتایج: 23477  

Journal: :The Journal of biological chemistry 2002
William Irwin Eric Fontaine Laura Agnolucci Daniele Penzo Romeo Betto Susan Bortolotto Carlo Reggiani Giovanni Salviati Paolo Bernardi

We have investigated the effects of the myotoxic local anesthetic bupivacaine on rat skeletal muscle mitochondria and isolated myofibers from flexor digitorum brevis, extensor digitorum longus, soleus, and from the proximal, striated portion of the esophagus. In isolated mitochondria, bupivacaine caused a concentration-dependent mitochondrial depolarization and pyridine nucleotide oxidation, wh...

Journal: :The American journal of sports medicine 2012
Sen Liu Qing-Song Zhang William Hester Michael J O'Brien Felix H Savoie Zongbing You

BACKGROUND Bupivacaine and supraphysiologic temperature can independently reduce cell viability of articular chondrocytes. In combination, these 2 deleterious factors could further impair cell viability. HYPOTHESIS Hyaluronan may protect chondrocytes from death induced by bupivacaine at supraphysiologic temperatures. STUDY DESIGN Controlled laboratory study. METHODS Bovine articular chond...

Journal: :Saudi medical journal 2014
Ming-Quan Chen Chun Chen Qi-Bin Ke

OBJECTIVE To determine the median effective dose (ED50) for motor block of intrathecally administered different concentrations of bupivacaine in younger patients. METHODS This study was conducted at the Department of Anesthesiology, The First College of Clinical Medical Science, China Three Gorges University, China, on 40 American Society of Anaesthesiologists (ASA) I-II younger patients (18-...

Journal: :Anesthesiology 2000
F Sztark K Nouette-Gaulain M Malgat P Dabadie J P Mazat

BACKGROUND Highly lipophilic local anesthetics interfere with mitochondrial energy metabolism. These metabolic effects could, in part, explain some toxic effects of local anesthetics, such as bupivacaine-induced myocardial depression. The purpose of this study was to compare the optically pure isomers of bupivacaine on heart mitochondrial bioenergetics. METHODS Both bupivacaine enantiomers we...

Journal: :International journal of obstetric anesthesia 2005
N Christelis J Harrad P R Howell

BACKGROUND Early studies suggested that ropivacaine had clinical advantages over bupivacaine with respect to cardiotoxicity and motor block, and that it was suitable for epidural caesarean section. This study was set up to compare epidural 0.75% ropivacaine with a popular bupivacaine/fentanyl mixture for elective caesarean section. METHODS Eighty women having elective caesarean section under ...

Journal: :Kathmandu University medical journal 2012
J Singh R S Shah N Vaidya P K Mahato S Shrestha B L Shrestha

BACKGROUND Caudal epidural analgesia with bupivacaine is very popular in paediatric anaesthesia for providing intra- and postoperative analgesia. Several adjuvants have been used to prolong the action of bupivacaine. OBJECTIVES To compare the efficacy of ketamine, fentanyl and clonidine in terms of quality and duration of analgesia they produce when added with caudal bupivacaine by single sho...

Journal: :Anesthesia and analgesia 2013
Kejian Shi Yun Xia Quanguang Wang Yiquan Wu Xiaoxi Dong Chanjuan Chen Wan Tang Yujian Zhang Mengxu Luo Xianqin Wang Thomas J Papadimos Xuzhong Xu

BACKGROUND While lipid emulsion may reverse the systemic toxicity of bupivacaine, the pharmacokinetics and tissue distribution of bupivacaine after lipid emulsion infusion are not clear. In this study, we assessed the influence of lipid emulsion administration on the pharmacokinetics and tissue distribution of bupivacaine. METHODS Rats in the lipid group were administered IV bupivacaine at th...

2012
Seyed Abbas Hosseini Jahromi Sadegh Sadeghi poor Seyedeh Masoumeh Hosseini Valami Amir Javadi

BACKGROUND The control of postoperative pain is important in children, and poor pain control leads to organ dysfunction and behavioral problems. OBJECTIVES We compared the analgesic effects of suppository acetaminophen, bupivacaine wound infiltration, and caudal block with bupivacaine on postoperative pain in pediatric inguinal herniorrhaphy. PATIENTS AND METHODS In this double-blinded, ran...

2015
Ke An Nabil M. Elkassabany Jiabin Liu

BACKGROUND Dexamethasone has been studied as an effective adjuvant to prolong the analgesia duration of local anesthetics in peripheral nerve block. However, the route of action for dexamethasone and its potential neurotoxicity are still unclear. METHODS A mouse sciatic nerve block model was used. The sciatic nerve was injected with 60ul of combinations of various medications, including dexam...

Journal: :British journal of anaesthesia 1993
C M Dryden I McMenemin D J Duthie

We studied 20 patients undergoing thoracotomy, in a double-blind, placebo-controlled crossover trial of intercostal bupivacaine. Bupivacaine 0.25% was infused at 5 ml h-1 through each of two catheters placed in the intercostal space at operation. Mean (95% confidence limits) 24-h requirements for morphine from a patient-controlled analgesia device were 29 (22-37) mg during bupivacaine infusion ...

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