PURPOSE The purpose of this study was to report a novel model for comparing mechanical resistance to intraocular pressure (IOP) increases with 23-gauge (23G) and 25G transconjunctival sutureless vitrectomy (TSV) sclerotomies in the immediate postoperative period using an experimental model of a vitrectomized eye. METHODS This was a prospective, experimental, randomized, and observer-masked ex...

Introduction: Diabetic macular edema (DME) is a debilitating complication of the diabetic eye. Vascular Endothelial Growth Factor (VEGF) was found to be responsible for this disease entity, and anti-VEGF remains main treatment DME. Inflammatory processes occur in eye, with some researchers postulates role them making This study’s objective search alternative using Non-Steroid Anti-Inflammatory ...

AIMS To investigate an influence of mucopolysaccharidosis (MPS)- and Morbus Fabry-associated corneal opacities on intraocular pressure (IOP) measurements and to evaluate the concordance of the different tonometry methods. METHODS 25 MPS patients with or without corneal clouding, 25 Fabry patients with cornea verticillata ≥ grade 2 and 25 healthy age matched controls were prospectively include...

We report the results of repeated ambulatory continuous 24-hour intraocular pressure (IOP) monitoring with a contact lens sensor (CLS) in a glaucoma patient with ocular pain after ab interno trabeculotomy (Trabectome™) surgery. Our findings show that a combined prostaglandin-pilocarpine treatment reduced nighttime IOP peaks and relieved the patient's symptoms.

To the Editor: We read with interest the study by Vetter et al, “Intraocular Pressure During Corneal Flap Preparation: Comparison Among Four Femtosecond Lasers in Porcine Eyes,” which appeared in the June 2011 issue of Journal of Refractive Surgery.1 Vetter et al measured the changes in intraocular pressure (IOP) during lamellar fl ap creation using four different femtosecond lasers. We also an...

Introduction Increased intraocular pressure (IOP) is a major risk factor for developing ocular disease such as primary open-angle glaucoma. Plasminogen activator inhibitor 1 (PAI-1) plays a role in the turnover and degradation of extracellular matrix proteins (ECM) which are thought to play a role in the pathogenesis of increased IOP. To determine if an independent association exists between se...

OBJECTIVES The current study was performed to assess the distribution of intraocular pressure (IOP) and its association with metabolic syndrome (MS) in a community. METHODS We measured IOP and MS components from 446 adults, age 20 or more years old, who reside in a community in Kyunggi Province, South Korea. We compared the level of IOP according to the number of metabolic abnormalities and b...

4-Biphenylacetic acid (BPAA),a prostaglandin-synthesis inhibitor, was tested for its effects on prostaglandin-related, laboratory models of ocular inflammation. Topically applied, BPAA inhibited arachidonic acid, but not prostaglandin E-induced increases in rabbit intraocular pressure (IOP). BPAA inhibited the IOP response to alkali burn and altered IOP changes following paracentesis. In vitro,...

Glaucoma is a chronic progressive disease that, left untreated, can lead to blindness. Glaucoma represents a range of conditions in which the flow of aqueous humor in the eye is blocked, causing an increase in intraocular pressure (IOP). Impaired blood flow to the optic disc may also cause glaucoma, even without an abnormally high IOP. Even with careful monitoring and lowering of IOP, approxima...

BACKGROUND To investigate the effect of primary phacoemulsification on intraocular pressure (IOP) in patients with acute primary angle-closure (PAC) and coexisting cataract. METHODOLOGY Sixteen eyes of 14 patients with acute PAC received phacoemulsification and intraocular lens implantation as initial management for medically uncontrolled IOP in a retrospective chart review. The effects on IO...