Metastatic survey of the patients with known primary malignancies with bone scan is one of the most common studies in nuclear medicine. Unfortunately the conventional planar bone scan has a very low specificity for differentiating benign from malignant lesions especially in the spinal column. In this study, we compared the specificity of SPECT imaging and convention...

Muscle mass and function are gradually lost in age-related, degenerative neuromuscular disorders, which also reflect the clinical hallmarks of sarcopenia. The consensus definition of sarcopenia includes a condition of age-related loss of muscle mass, quality, and strength. The most common acquired muscle disease affecting adults aged over 50 years is sporadic inclusion body myositis (sIBM). Bes...

A new mouse virus has been recovered from laboratory and wild mice. The agent induces a non-fatal disease in infant mice, characterized by acute massive necrosis of the thymic medulla and cortex, granulomatous reaction, and subsequent restoration of essentially normal architecture with scarring. Intranuclear inclusion bodies are produced. Virus may persist in tissues of convalescent mice for ma...

A fatal case of vaccinia necrosum treated with antivaccinial gamma globulin and N-methyl isatin beta-thiosemicarbazone (33T57) is described. Histological abnormalities found at necropsy included intranuclear as well as cytoplasmic inclusion bodies, absence of lymphoid germinal centres, grey hepatization, and bronchiolar epithelial hyperplasia. Virus titres were highest in the original skin lesi...

ABs'rRAcr. Nine aborted t'ctuses and orrc newborn calf, diagnosed as Chlamydia psittaci (C. psittaci) infection, were pathologica]ly examined. Thc characteristic lesions in the liver were focal necrosis in 9 aborted fetuses anci granulomatot]s necrotic foci in the newborn ca]f, Moderate numbers of intranuclcar inclusion bodies werc found in necrotic foci of the]iver, spleen, thymus, ]ymph nodes...

Morphological investagations were carried out on basophilic intranuclear and cytoplasmic inclusion bodies in epithelial cells of the hair bulbs of anagen hair follicles in wild foxes affected with an abnormal hair coat condition. The inclusions , which were DNA-positive, contained numerous minute virus-like particles ("FMVP"). The particles, having a diameter of approximately 13 nm, had an arra...

A study of experimental infectious canine hepatitis in dogs by means of specific fluorescent antibody indicates that the intranuclear inclusions of this disease contain high concentrations of viral antigen. The increase in virus in the nuclei, as indicated by the accumulation of specific antigenic material, begins on the nuclear membrane and spreads from there to the interior of the nucleus, wi...

Degeneration of cerebellar cortex is one of the principal features of hereditary ataxias linked to expansion of CAG repeat. In an attempt to clarify possible correlation between neuronal depletion and neuronal intranuclear inclusions, both triggered by the pathological expansion of CAG repeat, cerebellar sections from SCA1, SCA2, SCA3, and DRPLA cases were immunostained with anti-ubiquitin or a...

A total of 15 morphological abnormalities characteristic of dyserythropoiesis were evaluated in bone marrow smears stained with May-Grunwald-Giemsa stain. Abnormalities were classified as: (a) anomalies of the nucleus (binuclearity, multinuclearity, nuclear lobulation, budding, fragmentation, chromatin lumping and pyknosis, intranuclear bridging, extrusion of the nucleus); and (b) anomalies of ...