BMS-181885, chemically 3-[[3-[4-(5-methoxy-4-pyrimidinyl)-1-piperazinyl]propyl]-1H-indol-5-yl]-4-methyl-3-cyclobutene-1,2,-dione free base (Figure 1), is a potential antimigraine agent. Similar to sumatriptan, a 5-HT agonist, the pharmacological activity of BMS-181885 is elicited by binding to 5-HT1-like receptors. A strong rationale to develop a 5-HT agonist to treat migraine episodes is becau...
