ranolazine is a new antianginal drug that is postulated to act through blocking of cardiac late sodium channels and improvement in cardiac blood flow. the present study has been carried out to investigate its possible effect on microcirculation of normal and diabetic rats’ cardiac muscle. methods: normal and diabetic rats were anesthetized. the chest was opened and a surface laser doppler flowm...

Several studies show that portions of intramyocardial coronary arteries are spared of arteriosclerosis, involving morphological, embryological, biochemical and pathophysiological aspects. Endothelial function is significantly affected in the segment of transition, as estimated by the vasoactive response to Ach. These findings suggest that myocardial bridge can provide protection against arterio...

The sepsis-induced intramyocardial inflammatory response results in decreased ventricular function and myocardial damage. Chemokines such as monocyte chemoattractant protein-1 causally contribute to retention of intramyocardial mononuclear leukocytes and subsequent ventricular dysfunction during endotoxemic shock in mice and, importantly, this effect is age dependent. It is therefore useful to ...

Citation: Zlabinger K, Lukovic D, Hemetsberger R, Gugerell A, Winkler J, Mandic L, Traxler D, Spannbauer A, Wolbank S, Zanoni G, Kaun C, Posa A, Gyenes A, Petrasi Z, Petnehazy Ö, Repa I, HoferWarbinek R, de Martin R, Gruber F, Charwat S, Huber K, Pavo N, Pavo IJ, Nyolczas N, Kraitchman DL and Gyöngyösi M (2018) Matrix Metalloproteinase-2 Impairs Homing of Intracoronary Delivered Mesenchymal Ste...

Cai, Dongqing, Jacquelyne M. Holm, Inga J. Duignan, Jingang Zheng, Munira Xaymardan, Andrew Chin, Victoria L. T. Ballard, Jonathan N. Bella, and Jay M. Edelberg. BDNF-mediated enhancement of inflammation and injury in the aging heart. Physiol Genomics 24: 191–197, 2006. First published December 13, 2005; doi:10.1152/physiolgenomics.00165.2005.—Aging is associated with shifts in autocrine and pa...