Intervertebral disc degenerative diseases have become a serious social health problem. However, there is no clinical treatment effectively retarding the progression of intervertebral disc degeneration. Crocin, which is extracted from saffron, has been proved to exert anti-inflammatory and anti-catabolic effects on intervertebral disc in vitro and ex vivo. In the present study, effects of crocin...

STUDY DESIGN Preliminary clinical trial. PURPOSE To determine the safety and initial efficacy of intradiscal injection of autologous platelet-rich plasma (PRP) releasate in patients with discogenic low back pain. OVERVIEW OF LITERATURE PRP, which is comprised of autologous growth factors and cytokines, has been widely used in the clinical setting for tissue regeneration and repair. PRP has ...

STUDY DESIGN Biomechanical in vitro study. OBJECTIVE To establish a reliable in vitro herniation model with human cadaver spines that enables evaluation of anular closure devices. SUMMARY OF BACKGROUND DATA Biomechanically, it is desirable to close anulus defects after disc herniation to preserve as much nucleus as possible. Multiple anular closure options exist to prevent reherniation. A r...

OBJECTIVE For multi-level spondylolysis patients, surgeons commonly choose to fix all the segments with pars interarticularis defect even those without slippage and not responsible for clinical symptoms. In this study, we tried to study the necessity of the preventative long-segment surgery for the defected segment without slippage in treatment of multi-level spondylolysis patients from a biome...

Percutaneous endoscopic discectomy (PED) is a minimally invasive technique for the treatment of lumbar foraminal or extraforaminal and foraminal disc herniations that represent up to 11% of all lumbar herniated discs (1-4) Another study defined that farlateral disc herniations, constituting 7% to 12% of all disc herniations, typically migrate cranially as they extended laterally, foraminally, a...