Notch signaling occurs through direct interaction between Notch, the receptor, and its ligands, presented on the surface of neighboring cells. Endocytosis has been shown to be essential for Notch signal activation in both signal-sending and signal-receiving cells, and numerous genes involved in vesicle trafficking have recently been shown to act as key regulators of the pathway. Defects in vesi...

5 Affiliations: 6 1 Laboratory of Biochemistry, Wageningen University, Stippeneng 4, 6708 WE, 7 Wageningen, The Netherlands. 8 2 Ghent University, Department of Plant Biotechnology and Bioinformatics, 9 Technologiepark 927, 9052 Ghent, Belgium 10 3 VIB Center for Plant Systems Biology, Technologiepark 927, 9052 Ghent, Belgium 11 4 Present address: Laboratory of Molecular Biology, Wageningen Uni...

in chronic myelogenous leukemia (cml), the mature granulocytes originate from a stem cell line harboring an abnormal chromosome, therefore it is possible that metabolic-functional abnormalities occur in the morphologically mature cells. in the present study, the phagocytic activity including intracellular killing, nitro blue tetrazolium (nbt) reduction, and phagocytosis were studied in 37 cml p...

Abstract Intracellular/autocrine complement proteins have emerged as critical regulators of human Th1 induction and contraction. T cells contain both intracellular C3 C5 activation systems, with C3aR1 C5aR1 stimulation driving cell homeostatic survival normal IFNg production, respectively. Here we demonstrate how the intracellular/autocrine system is regulated by using from first described pati...

Studies in C. elegans have begun to reveal new components and new mechanisms associated with intracellular membrane traffic in a variety of cell types. The worm benefits from many of the advantages of yeast as a genetically tractable organism for these kinds of studies while offering the unique opportunity to probe how these pathways have been extended and modified in the context of a multicell...

Normal human red cells which have had their intracellular sodium (Na(c)) reduced have a diminished Na-K pump rate, but only if intracellular potassium (K(c)) is high. If most of the K(c) is replaced by tetramethylammonium or choline, both ouabain-sensitive Na efflux and K influx are significantly increased even with Na(c) below normal. Cells with reduced Na(c) and high K(c) have an unchanged Na...

s100ß a neurotrophic factor mainly released by astrocytes, has been implicated in the pathogenesis of bipolar disorder. thus, lithium may exert its neuroprotective effects to some extent through s100ß. furthermore, the possible effects of lithium on astrocytes as well as on interactions between neurons and astrocytes as a part of its mechanisms of actions are unknown. this study was undertaken...

objective(s):many studies have reported that tea consumption decreases cardiovascular risk, but the mechanisms remain unclear. green tea is known to have potent antioxidant and free radical scavengingactivities. this study aimed to investigate whether green tea extract (gte) can protect endothelial progenitors cells (epcs) against oxidative stress through antioxidant mechanisms. materials and m...