Vaccines are critical tools for the prevention and treatment of several diseases. Adjuvants have been traditionally used to enhance immunity to vaccines and experimental antigens. In the present study, the adjuvant combination of CpG oligodeoxynucleotides (CpG ODN) and the innate defense regulator (IDR) peptide, IDR‑HH2, was evaluated for its ability to enhance and modulate the immune response ...

This article bridges the permutation test of Moran’s I to the residuals of a loglinear model under the asymptotic normality assumption. It provides the versions of Moran’s I based on Pearson residuals (IPR) and deviance residuals (IDR) so that they can be used to test for spatial clustering while at the same time account for potential covariates and heterogeneous population sizes. Our simulatio...

Attempts to revisit Milgram's 'Obedience to Authority' (OtA) paradigm present serious ethical challenges. In recent years new paradigms have been developed to circumvent these challenges but none involve using Milgram's own procedures and asking naïve participants to deliver the maximum level of shock. This was achieved in the present research by using Immersive Digital Realism (IDR) to revisit...

PURPOSE Interdisciplinary rounds (IDRs) in the intensive care unit (ICU) are increasingly recommended to support quality improvement, but uncertainty exists about assessing the quality of IDRs. We developed, tested, and applied an instrument to assess the quality of IDRs in ICUs. MATERIALS AND METHODS Delphi rounds were done to analyze videotaped patient presentations and elaborated together ...

During strong earthquake excitations, base-isolated buildings may collide, either with the surrounding moat wall or with adjacent buildings if the available clearance is exceeded. This undesirable possibility has been recently investigated by several researchers, adopting various types of force-based impact models. Evidently, an important issue that arises regarding such numerical studies is th...

An American Medical Directors Association (AMDA) policy on the role of the medical director, based on a position statement approved by the association in 2003, indicates that the medical director should review, respond to, and participate in federal, state, local, and other external surveys and inspections.1 Anecdotal discussions at annual AMDA symposia and state chapter meetings suggest that a...

In periodically driven chaotic dynamical systems with a broad distribution of intrinsic time scales, perfect phase synchronization cannot be reached. Long segments of evolution during which the phase of a chaotic variable follows the phase of the driving force are interrupted by short segments of phase drift. We demonstrate that this drift is another short-lived synchronized state; its onset is...

PURPOSE To investigate the quantitative impact of frequency drift on Gamma-Aminobutyric acid (GABA+)-edited MRS of the human brain at 3 Tesla (T). METHODS Three sequential GABA+-edited MEGA-PRESS acquisitions were acquired in fifteen sessions; in ten of these, MRS was preceded by functional MRI (fMRI) to induce frequency drift, which was estimated from the creatine resonance at 3.0 ppm. Simul...

The intrinsically disordered region (IDR) of a protein is an important topic in molecular biology. The functional significance of IDRs typically involves gene-regulation processes and is closely related to posttranslational modifications such as phosphorylation. We previously reported that the Drosophila facilitates chromatin transcription (FACT) protein involved in chromatin remodeling contain...

Intrinsically disordered regions (IDRs) are fundamental units of protein function and regulation. Despite their inability to form a unique stable tertiary structure in isolation, many IDRs adopt a defined conformation upon binding and achieve their function through their interactions with other biomolecules. However, this requirement for IDR functionality seems to be at odds with the high entro...