objectives: postsurgical adhesion is one of the common complications after surgery. some anti-adhesion barriers are commercially available which are not customary used by physicians as much as expected because of ineffectiveness. recently, nanofibers have been introduced as anti-adhesion barriers with the potential of drug delivery. in the light of role of inflammation and oxidative stress in a...

buccoadhesive drug delivery systems have distinct advantages in comparison with oral administration. plant exudates like gum or mucilage are being studied for their use as pharmaceutical adjuvant. the aim of this study is to evaluate the properties of the plantago major seed mucilage as a mucoadhesive agent and propranolol hydrochloride is chosen as a model drug. mucoadhesive tablets of propran...

Superporouse hydrogel (SPH) is widely used and investigated as a gastro retentive drug delivery system to extend residence time in the stomach
 
 However, their mechanical strength represents problem because they need withstand peristaltic movement of stomach. Properties SPH are affected by materials for synthesis. The aim research study effect changing foaming agent foam stabilizer a...

A new general route for siRNA delivery is presented combining porous core-shell silica nanocarriers with a modularly designed multifunctional block copolymer. Specifically, the internal storage and release of siRNA from mesoporous silica nanoparticles (MSN) with orthogonal core-shell surface chemistry was investigated as a function of pore-size, pore morphology, surface properties and pH. Very ...

The objective of this study was to demonstrate that asymmetric membrane capsules can be used to deliver a poorly water soluble drug with a pH dependent solubility, such as carvedilol, for extended periods of time by modulating solubility with acid. In this study, the effect of the concentration of pH regulating agent and osmotic agents on the release rate of the active material was investigated...

Wood shrinks during drying with the departure of bond water. Along the fibre direction, the magnitude of this shrinkage is mainly governed by the orientation of cellulose microfibrils (MF) in the cell wall. However, tension wood has an unexpectedly high longitudinal shrinkage considering the fact that MFs are oriented nearly parallel to the cell direction. This effect is thought to be due to th...

Purpose: Ofloxacin is a fluoroquinolone with broad-spectrum antibacterial action, used in treatment of systemic and local infections. Ofloxacin is BCS class II drug having low solubility, high permeability with short half-life. The present work was aimed to design, develop and optimize gellified emulsion of Ofloxacin to provide site targeted drug delivery. Transdermal drug delivery will enhance...

In autonomous agent systems, internal memory can be an important element to overcome the limitations of purely reactive agent behaviour. This paper presents an analysis of memory requirements for T-maze tasks well known as the road sign problem. In these tasks a robot agent should make a decision of turning left or right at the T-junction in the approach corridor, depending on a history of perc...

HIV-1, the agent of the AIDS pandemic, is an RNA virus that reverse transcribes its RNA genome (gRNA) into DNA, shortly after its entry into cells. Within cells, retroviral assembly requires thousands of structural Gag proteins and two copies of gRNA as well as cellular factors, which converge to the plasma membrane in a finely regulated timeline. In this process, the nucleocapsid domain of Gag...