S U M M A R Y We examine a variety of mechanisms that have been proposed as contributors to the stress fields expressed as intermediate-depth seismicity in subducting slabs. To this end, we study principal stress orientations for a global data set of 1900 intermediate-depth focal solutions, determining the patterns of events characterized primarily by downdip compression, downdip tension, or ne...

BACKGROUND Type 2 diabetes mellitus (T2DM) patients are at increased risk of developing cardiovascular events. Unfortunately traditional risk assessment scores, including the Framingham Risk Score (FRS), have only modest accuracy in cardiovascular risk prediction in these patients. METHODS We sought to determine the prognostic values of different non-invasive markers of atherosclerosis, inclu...

Myocardial infarction and stroke often occur without prior warning in asymptomatic individuals. Identifying individuals at risk is important for cost-effective use of preventive therapies. Algorithms based on risk factors statistically associated with cardiovascular events classify individuals into high-risk, intermediate-risk, or low-risk categories. However, more than one-third of adults in t...

Massive black holes (BHs) at the centres of massive galaxies are ubiquitous. The population BHs within dwarf galaxies, on other hand, is not yet known. Dwarf thought to harbour with proportionally small masses, including intermediate-mass BHs, masses 102 < MBH 106 solar (M⊙). Identification these systems has historically relied detection light emitted from accreting gaseous disks close BHs. Wit...

Abstract Massive black holes in the centers of galaxies today must have grown by several orders magnitude from seed formed at early times. Detecting a population intermediate mass (IMBHs) can provide constraints on these elusive BH seeds. Here we use large volume, cosmological hydrodynamical simulation Astrid, which includes IMBH seeds and dynamical friction to investigate Dynamical is largely ...

BACKGROUND Genetic variants have been associated with the risk of coronary heart disease. In this study, we tested whether or not a composite of these variants could ascertain the risk of both incident and recurrent coronary heart disease events and identify those individuals who derive greater clinical benefit from statin therapy. METHODS A community-based cohort study (the Malmo Diet and Ca...

BACKGROUND The use of opioids for neuropathic pain remains controversial. Studies have been small, have yielded equivocal results, and have not established the long-term risk-benefit ratio of this treatment. OBJECTIVES To assess the efficacy and safety of opioid agonists for the treatment of neuropathic pain. SEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (2n...

INTRODUCTION AND OBJECTIVES Detection of carotid atherosclerosis might help to better identify individuals susceptible to cardiovascular events. We aimed to quantify the number of participants with carotid atherosclerosis and low-to-intermediate cardiovascular risk according to the traditional risk factor scoring, and therefore with an elevated risk of cardiovascular events. METHODS Cross-sec...

Short pulse-labeling of log phase Crithidia fasciculata cells with [3H]thymidine allowed the autoradiographic visualization of 2 sites of replication of kinetoplast DNA situated at the periphery of the networks and separated by 180 degrees. Longer pulse-labeling led to the previously reported total peripheral labeling pattern. Pulse-labeled networks possess an intermediate density in ethidium b...

Angiogenesis is the formation of new blood vessels from pre-existing structures, and is a key step in tissue and organ development, wound healing and pathological events. Changes in cell shape orchestrated by the cytoskeleton are integral to accomplishing the various steps of angiogenesis, and an intact cytoskeleton is also critical for maintaining newly formed structures. This review focuses o...