Mechanisms that regulate oligodendrocyte survival and myelin formation are an intense focus of research into myelin repair in the lesions of multiple sclerosis (MS). Although demyelination and oligodendrocyte loss are pathological hallmarks of the disease, increased oligodendrocyte numbers and remyelination are frequently observed in early lesions, but these diminish as the disease course progr...

Objective(s): In the present study, C57BL/6 female mice (n=56) were used to explore the neuroprotective effects of riboflavin in motor disability of experimental autoimmune encephalomyelitis (EAE) as a model of multiple sclerosis. Materials and Methods: The animals were assigned into 7 groups: sham-operated 1 (SO1), healthy mice receiving PBS (phosphate buffer saline); sham-operated 2 (SO2), h...

Accumulating evidence suggests that patients with active pulmonary tuberculosis (TB) have an alveolar inflammation resulting in the release of tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta in bronchoalveolar epithelial fluid. It was proposed that the levels of these cytokines would correlate with clinical status parameters (extent of pulmonary involvement, fever, and body weight...

results when the two ms groups were compared together, we found that cr was significantly increased (p value=0.008) and naa/cr was significantly decreased (p value=0.03) in non-enhancing lesions in ppms compared with rrms. there was no significant difference in naa, cho or naa/cho between the two ms subtypes. conclusion mrs is a potential way to differentiate ppms and rrms. objectives we compar...

background: cognitive  impairment  is one of the  most crucial disorders  among  multiple  sclerosis (ms) patients. since  ms  is  an inflammatory disease   and   boswellia papyrifera has anti-inflammatory effects, the influence of b. papyrifera  on  cognitive  impairment   in  ms patients   has been investigated  in the present study. methods: in this clinical trial, 80 ms patients  who referr...

© 2015 The Authors. doi: 10.2340/00015555-2104 Journal Compilation © 2015 Acta Dermato-Venereologica. ISSN 0001-5555 Primary localized cutaneous amyloidosis (PLCA; MIM 105250) is a chronic itchy skin disorder associated with amyloid deposits in the superficial dermis (1). Clinically, most skin lesions comprise small, flat-topped papules (lichen amyloidosis) or brown-grey macules (macular amyloi...

Panax notoginseng saponins are often used to treat a frequently of inflammatory diseases, but the underlying mechanisms their effects on human osteoarthritis limited. An model was established by interleukin-1 beta treatment chondrocytes for experiments. During experiment, cell activity detected 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide method. The enzymelinked immunosorbent ...