Background and Objective: Genetic factors greatly impact the response to treatment in patients. Recent studies on rs10853728 single nucleotide polymorphisms in the promoter area, determined the IL-28B gene as a host factor affecting the treatment of hepatitis C infection. The aim of this study was to evaluate this polymorphism among Iranian patients Materials and Methods: This cross-sectiona...

Introduction: Helicobacter pylori is the main cause of chronic inflammation and peptic ulcer. More than half of the world population is afflicted with Helicobacter, while only 20% of people show the clinical symptoms of the disease. Genes encoding the cytokines interleukin (IL)-1B play a key role in the inflammatory responses of gastric mucus. This study aims to analyze polymorphism in the IL-1...

Background& Objective: Host resistance towards Leishmania infection is mediated by cellular immune responses leading to macrophage activation and parasite killing. According to the important role of IL-13 in the defense against visceral leishmaniasis (VL) and the known effect of the IL-13 gene polymorphisms on its production, the aim of this study was to investigate the probable relationship be...