Protein domains are evolutionarily-conserved structural or functional subunits in proteins that are suggestive of the proteins’ propensity to interact or form a stable complex. In this paper, we propose a novel domain-based probabilistic classification method to predict protein-protein interactions. Our method learns the interacting probabilities of domain pairs based on domain pairing informat...

Inflammation is induced because of interplay among multiple signaling pathways and molecules during infectious and noninfectious tissue injuries. Crosstalk between Toll-like receptor-4 signaling and the neuronal apoptosis inhibitor protein, major histocompatibility class 2 transcription activator, incompatibility locus protein from Podospora anserina, and telomerase-associated protein (NACHT), ...