Background We present a software prototype that allows for preinterventional planning and simulation of focused ultrasound therapies. By using numerical simulation techniques the heating and destruction of the tissue can be predicted and thus a patient-specific treatment plan can be generated in advance. Since our simulation is amenable to respect rib shielding, organ motion as well as focal po...

[15] Beerlage HP, van Leenders JLH, Oosterhof GON, Witjes JA,van de Kaa CA, Debruyne FMJ, et al. High-intensity focused ultrasound followed after one to two weeks byradical retropubic prostatectomy: Results of a prospectivestudy. Prostate 1999;39:41–6. [16] Beerlage HP, Thuroff S, Debruyne FMJ, Chaussy C, de la Rosette JJMCH. Transrectal high-intensity focused ultrasound using t...

High-intensity focused ultrasound (HIFU) is deemed to be a promising noninvasive therapeutic modality for cancers as well as non-neoplastic diseases. However, the accuracy of the technique in the diagnosis and treatment of tumors remains unsatisfactory. HIFU, when combined with multifunctional synergistic agents (SAs), has the potential to be of greater diagnostic and therapeutic efficacy. Here...

We report the development of photoacoustic flowmetry assisted by high-intensity focused ultrasound (HIFU). This novel method employs HIFU to generate a heating impulse in the flow medium, followed by photoacoustic monitoring of the thermal decay process. Photoacoustic flowmetry in a continuous medium remains a challenge in the optical diffusive regime. Here, both the HIFU heating and photoacous...

ii Acknowledgements iii Table of

Cavitation often occurs in therapeutic applications of medical ultrasound such as shock-wave lithotripsy (SWL) and high-intensity focused ultrasound (HIFU). Because cavitation bubbles can affect an intended treatment, it is important to understand the dynamics of bubbles in this context. The relevant context includes very high acoustic pressures and frequencies as well as elevated temperatures....

Background Mild hyperthermia (41.5-44°C) has been shown to enhance the effect of radiotherapy and chemotherapy. However, currently available heating methods are often inefficient in inducing conformal hyperthermia for deep seated targets. Here, the software of Philips Sonalleve V2 MR-HIFU system was modified to enable performing a long duration large volume hyperthermia sonication in in-vivo po...

High-intensity focused ultrasound (HIFU) competes with radiofrequency and cryotherapy for the treatment of small renal masses as a third option among ablative approaches. As an emerging technique, its possible percutaneous or laparoscopic application, low discomfort to the patient and the absence of complications make this technology attractive for the management of small renal masses. This man...