Phase change of pore fluid (boiling/condensing) in rock cores under conditions representative of geothermal reservoirs results in alterations of the electrical resistivity of the samples. In fractured samples, phase change can result in resistivity changes that are more than an order of magnitude greater than those measured in intact samples. These results suggest that electrical resistivity mo...

p120-Catenin (p120) functions as a tumor suppressor in intestinal cancer, but the mechanism is unclear. Here, using conditional p120 knockout in Apc-sensitized mouse models of intestinal cancer, we have identified p120 as an "obligatory" haploinsufficient tumor suppressor. Whereas monoallelic loss of p120 was associated with a significant increase in tumor multiplicity, loss of both alleles was...

Spectrin is a cytoskeletal protein that plays a role in formation of the specialized plasma membrane domains. However, little is known of the molecular mechanism that regulates responses of spectrin to extracellular stimuli, such as activation of G-protein-coupled receptor (GPCR). We have found that alphaII spectrin is a component of the Galpha(q/11)-associated protein complex in CHO cells stab...

The deep rock masses show a different mechanical behavior compared with the shallow rock masses. They are classified into alternating fractured and intact zones during the excavation, which is known as zonal disintegration. Such phenomenon is a great disaster and will induce the different excavation and anchoring methodology. In this study, a 3D geomechanics model test was conducted to research...

Background: Negative regulatory mechanisms of ROCK signaling are poorly understood. We have discovered a novel mechanism to attenuate ROCK signaling. Results: Coronin1B is a novel binding partner of ROCK2 that inhibits ROCK signaling to myosin. Conclusion: Coronin1B regulates ROCK by a novel signal attenuation mechanism. Significance: Coronin1B attenuation of ROCK signaling is associated with N...

Rock bolts have been widely used as rock reinforcing members in underground coal mine roadways and tunnels. Failures of rock bolts occur as a result of overloading, corrosion, seismic burst and bad grouting, leading to catastrophic economic and personnel losses. Monitoring the health condition of the rock bolts plays an important role in ensuring the safe operation of underground mines. This wo...

[1] Experimental data for alteration of synthetic Martian basalts at pH = 0–1 indicate that chemical fractionations at low pH are vastly different from those observed during terrestrial weathering. Rock surface analyses from Gusev crater are well described by the relationships apparent from low-pH experimental alteration data. A model for rock surface alteration is developed, which indicates th...

We studied the elastic moduli, ductile creep behavior, and brittle strength of shale-gas reservoir rocks from Barnett, Haynesville, Eagle Ford, and Fort St. John shale in a series of triaxial laboratory experiments. We found a strong correlation between the shale compositions, in particular, the volume of clay plus kerogen and intact rock strength, frictional strength, and viscoplastic creep. V...

This work evaluates the effect of high temperatures and cooling methods on drillability Prada limestone. Samples from boreholes drilled during design stage Tres Ponts Tunnel in Catalan south Pyrenean zone (Spain) were subjected to 105, 200, 300, 400, 600 °C, then cooled at a slow rate or by quenching. Sievers’ J-value (SJ) brittleness (S20) determined thermally treated samples, drilling index (...

In terms of target detection and classification, scattering from exposed rock on the seafloor, (i.e., individual rocks and rock outcrops) presents some of the most difficult challenges for modern MCM and ASW sonar systems in shallow water. Work on characterizing, modeling and simulating mean levels and other statistical measures of acoustic scattering from rocks and rock outcrops is therefore c...