The incidence of diabetes mellitus and hypertension continues to rise worldwide. The proportion of patients with hypertension at risk for developing diabetes mellitus is also growing secondary to aging and increased obesity rates.1 Several guidelines recommend thiazide diuretics as either first-line or add-on antihypertensive therapy to achieve blood pressure goals.2 Concern over negative metab...

................................................................................4 BACKGROUND..........................................................................5 §1.0. Glucose Homeostasis......................................................................5 1.1. Pancreatic beta-cells..............................................................5 1.2.Insulin..................................

BACKGROUND Pancreatic beta cells express ATP-sensitive potassium (KATP) channels that are needed for normal insulin secretion and are targets for drugs that modulate insulin secretion. The KATP channel is composed of two subunits: a sulfonylurea receptor (SUR 1) and an inward rectifying potassium channel (Kir6.2). KATP channel activity is influenced by the metabolic state of the cell and initia...

Rana I. Shakoor Pakistan Institute of Engineering & Applied Sciences, Islamabad Pakistan [email protected] Tele: +9251 2207381 Fax: +92 51 2208070 Shafaat A. Bazaz GIK Institute of Engineering Sciences & Technology, Topi, Pakistan [email protected] Y. Lai Queens University, Kingston, ON, Canada, K7L3N6 [email protected] M. M. Hasan Pakistan Institute of Engineering & Applied Sciences, Islama...

Corrigendum Corrigendum to ‘‘Application of the optimal homotopy asymptotic method to squeezing flow’’ [Comput. Math. Appl. 59 (2010) 3858–3866] M. Idrees a, S. Islam b,∗, Sirajul Haq a, Siraj-ul-Islam c a Faculty of Engineering Sciences, GIK Institute, Topi, NWFP, Pakistan b Department of Mathematics, CIIT, H-8/1, Islamabad 44000, Pakistan c NWFP University of Engineering and Technology, Pesha...

The effects on haemodynamics and infarct size (measured by total creatine kinase release) of intravenous infusions of normal saline, glucose, or glucose-insulin-potassium were studied in 36 patients with transmural acute myocardial infarction qf less than 12 hours' duration. In 12 patients, 2 ml/kg 50 per cent glucose (5.55 mmol/kg) was given over 10 minutes with 0 4 unit/kg soluble insulin 5 m...

It is well recognized that intrauterine growth restriction leads to the development of insulin resistance and type 2 diabetes mellitus in adulthood. To investigate the mechanisms behind this "metabolic imprinting" phenomenon, we examined the impact of maternal undernutrition on insulin signaling pathway and the ATP sensitive potassium channel expression in the hypothalamus of intrauterine growt...