background and aim: the aim of this study was to determine the effect of legume intake in therapeutic lifestyle change (tlc) on fasting insulin, fasting blood glucose, hba1c and homeostasis model assessment insulin resistance (homa-ir) in patients with type 2 diabetes. materials and methods: in this randomized crossover trial, 31 subjects with type 2 diabetes in the age range of 50 to 80 years ...

Diabetes mellitus is a group of metabolic diseases. Insulin resistance is defined as a state that needs more insulin to get the biological effects achieved by a lower amount of insulin in the normal state. Several molecules which are secreted through adipocytes have been involved in insulin resistance and type 2 diabetes mellitus. Adiponectin as a 244 amino acid protein is exclusively expressed...

abstract background: better control of blood sugar and reduction of diabetes complications through insulin therapy could convince people to choose this method. however, patients might refuse insulin therapy due to its painful injection, limitations in daily activities, and hypoglycemia. thus, insulin therapy could have both positive and negative effects on patients’ quality of life (qol). there...

introduction: numerous evidence indicates the involvement of insulin and k atp channel blockers in brain functions such as memory. materials & methods: in this study, by applying light (h & e staining) and scanning electron microscopies, we investigated the effect of intrahippocampal injection of insulin, glibenclamide experimental diabetic rats. may these reverse the cellularimpairment, and pr...

This study was designed to investigate the anti-diabetic effects of selenium nanoparticles (SeNPs) at dose 2 mg/kg body weight in streptozotocin (STZ) induced diabetes rats 50 weight. Were administered orally normal and experimentally diabetic for 35 days glibenclamide (Glib) rate 20 used as a reference drug. 48 waster male divided into 6 equal groups each 8 rats. Blood samples pancreatic tissu...

Diabetes is a metabolic disorder characterized by hyperglycemia, altered carbohydrate, lipid and protein metabolism. In recent studies, Nanoscience and nanotechnology are blazing fields for researchers; for researchers; of late there has been a prodigious excitement in the field of nanopharmacology to study silver nanoparticle (SNP) synthesis using natural products. Biological methods have been...

BACKGROUND Success of any gene therapy protocol relies mostly on using an efficient carrier to direct nucleic acid to the place of action. The system should also have transfection ability at release site. Different routes are available for delivering genetic materials to the target organs, amongst them; oral delivery is particularly attractive for certain reasons. However, serious obstacles, li...

This article mainly discusses the mechanism of SINOMENINE nanoparticles in treatment breast cancer by using network pharmacology method. TCMSP and Swiss Target Prediction databases were searched for target SINOMENINE. The was through GeneCards database. common targets both considered as treating cancer. software Cytoscape 3.7.1 used topological analysis visualization. DAVID GO enrichment analys...