In its complexity and its vulnerability to market volatility, the CPDO might be viewed as the poster child for the excesses of financial engineering in the credit market. This paper examines the CPDO as a case study in model risk in the rating of complex structured products. We demonstrate that the models used by S&P and Moody’s would have assigned very low probability to the spread levels real...

There has been relatively little effort to provide a systematic overview of different forms of exploratory experimentation (EE). The present paper examines the growing subdiscipline of nanotoxicology and suggests that it illustrates at least four ways that researchers can engage in EE: searching for regularities; developing new techniques, simulation models, and instrumentation; collecting and ...

A state-of-the-art chamber facility is described for investigation of atmospheric aerosol chemistry. Dual 28 m3 FEP Teflon film chambers are used to simulate atmospheric conditions in which aerosol formation may occur. This facility provides the flexibility to investigate dark, single oxidant reactions as well as full photochemical simulations. This paper discusses the environmental control imp...

Application Note Technological advances in analytical instrumentation and computing systems have allowed many industries to better monitor and control business critical processes. This has enabled proactive, not reactive approaches to real-time quality assurance and product release. Until the advent of QbD and subsequent PAT initiatives, pharmaceutical and related industries were not fully equi...

The resolution gap between macromolecular crystallography and electron microscopy continues to decrease. Recent advances in specimen preparation, instrumentation and computational power have allowed accurate structure determination of larger macromolecular complexes by crystallography and/or by electron microscopy on cryovitrified samples. New possibilities in structural biology have opened up ...

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Instrumentation has been developed to acquire and record performance data for analysis of Navy communications systems. The existing two basic models are modular, multimicroprocessor-based systems using state-of-the-art devices. They were designed to collect, process, and record performance data automatically (i.e., with little or no operator intervention). One is designed as a shipborne system,...

We provide a broad review of approaches for developing chemosensor systems whose operating parameters can adapt in response to environmental changes or application needs. Adaptation may take place at the instrumentation level (e.g., tunable sensors) and at the data-analysis level (e.g., adaptive classifiers). We discuss several strategies that provide tunability at the device level: modulation ...