Thermoresponsive ionic liquid hydrogel delivery vehicles of reduced gelation temperature for injectable and controlled drug applications.

Degradable and injectable hydrogels may be ideal for bone-tissue engineering, especially in the craniofacial region because of the ease of access for injection. Alginate hydrogels potentially could be used as injectable cell delivery vehicles, but they exhibit a limited range of mechanical properties and uncontrollable disintegration time. Therefore we synthesized new hydrogels, composed of pol...

Long-acting injectable antipsychotics provide the delivery of medication over an extended period of time requiring administration typically only every 2 to 4 weeks. The side effect profile of a long-acting injectable antipsychotic is predictable and similar to the oral formulation. However, injection site reactions may occur with this novel delivery system. The risk of an injection site reactio...

Engineering craniofacial bone tissues is challenging due to their complex structures. Current standard autografts and allografts have many drawbacks for craniofacial bone tissue reconstruction; including donor site morbidity and the ability to reinstate the aesthetic characteristics of the host tissue. To overcome these problems; tissue engineering and regenerative medicine strategies have been...

Soft tissue augmentation is a process of implanting tissues or materials to treat wrinkles or soft tissue defects in the body. Over the years, various materials have evolved to correct soft tissue defects, including a number of tissues and polymers. Autogenous dermis, autogenous fat, autogenous dermis-fat, allogenic dermis, synthetic implants, and fillers have been widely accepted for soft tiss...

Avariety of injectable fillers have been employed to correct the stigmatizing facial lipoatrophy associated with HIV infection. A novel filler is Bio-Alcamid (Bio-Alcamid, Polymekon, Milan, Italy), which has been described as an injectable ‘‘endoprosthesis.’’ This nonbiodegradable filler is composed of 96% water and 4% synthetic polymer polyalkylamide and is purported to be biologically inert. ...

In full-thickness wounds, inflammation, lack of matrix deposition, and paucity progenitor cells delay healing. As commercially available solid (sheet) scaffolds are unable to conform wounds varying shapes sizes, we previously generated a nutritious, injectable, liquid skin substitute that can wound topography. combination with adipose micro-fragments as viable source cells, composite, in situ f...

Injectable hydrogels are becoming increasingly important in the fields of tissue engineering and drug delivery due to their tunable properties, controllable degradation, high water content, and the ability to deliver them in a minimally invasive manner. Shear-thinning is one promising technique for the application of injectable hydrogels, where preformed hydrogels can be injected by application...

INTRODUCTION: The use of injectable scaffolds has raised great interest as they minimise the need for invasive surgery and its associated complications, costs and discomfort to the patient. Furthermore, they can fill cavities of any size or shape as well as being able to deliver a localised therapeutic agent [1]. The aim of this study was to develop an injectable scaffold using PLGA micropartic...

Injectable contraceptives are fast becoming the method of choice among married women in sub-Saharan Africa. In several countries in the region, the proportion of women using injectable methods has surpassed the proportion of women using the pill. This is true even in some countries where the pill had been the most popular modern method in the 1980s and 1990s. This paper analyzes data from six s...