The molecule BV-1 is designed to target the bacterial membrane and produce reactive oxygen species at this location, leading E. coli photo-inhibition a relatively low minimum inhibition concentration.

Onion (Allium Cepa) contains high levels of flavonoids. Although there are many studies indicating the inhibitory effects of flavonoids on xanthine oxidase, there is no report on the effect of onion on this enzyme. Therefore, in the present study, the inhibitory effects of onion on xanthine oxidase are investigated. Fresh filtered juice of onion was prepared and its inhibitory effect on guine...

addition of n-butyl nitrite to isolated rat hepatocytes caused an immediate glutathione depletion followed by an inhibition of mitochondrial respiration, inhi- bition of glycolysis and atp depletion. at cytotoxic butyl nitrite concentrations, lipid  peroxidation  occurred  before  the  plasma  membrane  was  disrupted. cytochrome p-450 inhibitors inhibited peroxynitrite formation and prevented ...

physalis angulata is a medicinal plant used for the treatment of malaria, ulcer, pains and other diverse ailments. the present study evaluated the analgesic and anti-inflammatory activity of methanolic leaf extract of the plant. acetic acid-induced abdominal contraction or writhing analgesic models in swiss albino mice (13-23g) were used for studying analgesic activity of the leaf extract. 200,...

the effects of hydroalcoholic extract (he) of curculigo orchioides gaertn. rhizome (hypoxidaceae) and its alkaloidal and non-alkaloidal fractions (af) and (naf) were evaluated in carrageenan-induced paw edema experimental models of inflammation. the oral administration of he, their af and naf fractions were used at doses of 100, 300 and 500 mg/kg. the effect produced by the he, af and naf fract...

introduction: evidence suggests that neuronal apoptosis in neurodegenerative diseases is correlated with inflammatory reactions. the beneficial or detrimental role of apoptosis in neuroinflammation is unclear. elucidating this question may be helpful in management of neurodegenerative diseases. since tnf-α is able to induce apoptosis as well as increased viability of the cells by activation of ...

An educational physical education (PE) hybridization program based on the personal and social responsibility model gamification strategies was used in order to explore effect cognitive performance academic achievement. A 9-month group-randomized controlled trial conducted, with 150 participants (age: 14.63 ± 1.38) allocated into control group (CG, n = 37) experimental (EG, 113). Inhibition, ver...

purpose : to investigate the penetration of cefixime and ciprofloxacin to the rabbit eye on the basis of microbial inhibition of aqueous and vitreous humour after oral administration. methods : in this experimental study, 36 rabbits (72 eyes) were randomly divided into two groups group a consisted of 20 rabbits and group b 16 rabbits. each group was divided into four equal subgroups. the rabbit...

background and objectives:alzheimer’s disease (ad) is a neurodegenerative disorder. nowadays, many investigations are performed to find new drugs for ad and medicinal plants are considered as one of the most important sources for developing new drugs. according to the role of oxidant agents and acetylcholinesterase enzyme (ache) in ad, plants with antioxidant and ache inhibition properties coul...

around 75% of civilians have experienced at least one traumatic event in their lives, and this number is considerably higher in many parts of the world, as well as in military veterans and first responders. of those exposed to trauma, 15-25% will develop posttraumatic stress disorder (ptsd).  ptsd extracts enormous economic, health, and quality of life cost. thus, it is critical to understand m...