Infertility is a condition that affects between one-fifth and one-sixth of couples of reproductive age. It is defined as a reduction in or a lack of ability to reproduce and its cause may lie either in the male or female partner (Stedman, 2006). According to the American Society for Reproductive Medicine, infertility should be considered when pregnancy fails to occur after one year of regular s...

Objectives: To assess the effect of variations in GTP cyclohydrolase gene (GCH1) on pain sensitivity in humans. Methods: Thermal and cold pain sensitivity were evaluated in a cohort of 735 healthy volunteers. Among this cohort, the clinical pain responses of 221 subjects after the surgical removal of impacted third molars were evaluated. Genotyping was done for 38 single nucleotide polymorphism...

Deficiencies of coagulation factors other than factor VIII and factor IX that cause bleeding disorders are inherited as autosomal recessive traits and are rare, with prevalences in the general population varying between 1 in 500 000 and 1 in 2 million for the homozygous forms. As a consequence of the rarity of these deficiencies, the type and severity of bleeding symptoms, the underlying molecu...

MEREDITH C. ROATH, MD JACK A. DI PALMA, MD University of South Alabama T he modern age of genetics began in the mid-19th century, and many scientific discoveries led to the sequencing of the human genome. Recent research has uncovered the genetic basis of many diseases, and continued study is certain to lead to more discoveries. The results of this research will continue to change medicine. Gen...

During an eight-year period (January 1991– anuary 1999) a total of 11,200 women were xamined at the breast out-patient Department of he University Hospital. Of these, 7,750 were registered for the first time and 3,450 repeated their visit for different reasons. Of the 7,750 women, breast cancer was diagnosed in 261, who were treated appropriately. Out of the 261 breast cancer patients 9 (3.44%)...

The lymphocyte function-associated 1 (LFA-1), ~ Mac-l, and p150,95 molecules constitute a family of structurally and functionally related, high molecular weight, human leukocyte surface glycoproteins (1). Each molecule contains an a and a 3 subunit noncovalently associated in an al31 structure. The 3 subunits of Mr 95,000 in each of these three molecules are identical. The molecules are disting...