Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease, which associated with an increased risk of cholangiocarcinoma (CCA). Novel markers, to complement or replace CA19-9, are urgently needed for the screening PSC-associated biliary neoplasia. Previous studies have suggested that serum trypsinogen-2 and human chorionic gonadotropin β-subunit (hCGβ) may serve as such markers. Us...

kidney disease (CKD) adds to their prognostic evaluation in terms of mortality. They conclude that the determination of inflammatory markers is not helpful if age and comorbidity are taken into account. It would, however, be appropriate if some further analyses were performed before such a conclusion is advanced. The conclusion of Caravaca et al. [1] is based on a multivariate Cox-regression an...

OBJECTIVE Procalcitonin is useful for the diagnosis of sepsis, but its prognostic value regarding mortality is unclear. Our objective was to determine the prognostic value of procalcitonin determined at the onset of sepsis, and to compare it with other markers of inflammatory response, malnutrition and organ dysfunction data. METHODS We studied 253 hospitalized patients (146 men, 107 women) w...

The objective of this prospective study was to identify baseline angiogenic and inflammatory markers in serum as well as the baseline levels of immune cells in whole blood to predict progression-free survival in patients with metastatic renal cell carcinoma treated with sunitinib. Blood samples were collected at baseline in all 90 patients to analyze serum angiogenic and inflammatory markers to...

AIM Hypercholesterolemic patients with inflammation are at high risk for cardiovascular events. Statins exert anti-inflammatory action independent of their cholesterol-lowering action. This study sought to clarify whether statin therapy reduces inflammatory markers in hypercholesterolemic patients and to determine factors that predict the reduction in these markers. METHODS Fasting concentrat...

Objective: Chronic obstructive pulmonary disease (COPD) is characterized by systemic inflammation and accelerated inflammaging of the lungs. Some studies showed that conjugated linoleic acid (CLA) has anti-inflammatory effects. The aim of the present study was to evaluate the effect of CLA supplementationon serum levels of interleukin (IL)-6 and sirtuin1 (SIRT1) in patients wit...

INTRODUCTION Abdominal fat mass is an important risk factor of inflammation in the general population as it is in haemodialysis (HD) patients. The aim of this study was to investigate the association of adiposity using the conicity index (Ci) with nutritional-inflammatory markers and to analyse whether these factors were related with the clinical outcome in HD patients. METHODS A cross-sectio...

INTRODUCTION Systemic inflammatory response in individuals with cancer is related to a progressive reduction in total body mass, especially lean mass. OBJECTIVE The aim of the present study was to determine the association between nutritional status and systemic inflammatory response in patients with gastrointestinal cancer. METHODOLOGY A case series study was carried out involving 30 male ...