Monocytes/macrophages are key players in all phases of physiological and pathological inflammation. To understanding the regulation of macrophage functional differentiation during inflammation, we designed an in vitro model that recapitulates the different phases of the reaction (recruitment, initiation, development, and resolution), based on human primary blood monocytes exposed to sequential ...

Selectin binding is the first step in extravasation of leukocytes through the endothelium. Infiltration of leukocytes is a hallmark of an inflammatory response. Blockade of selectin-dependent adhesion, therefore, represents a specific mechanism-based anti-inflammatory strategy. We have used the natural product sulfatide, one of the selectin ligands, as a template to design a novel selectin anta...

The viral-induced perivascular inflammatory response in Sindbis virus encephalitis of mice was shown to be immunologically specific. Mice were inoculated intracerebrally with Sindbis virus, and 24 hr later a single dose of cyclophosphamide was given which ablated the inflammatory response. 3 days after virus inoculation, cells and/or sera from specifically and nonspecifically sensitized donor m...

Search for a novel anti-inflammatory agent from a herbal source, such as Eupatorium adenophorum Spreng., a plant from the Eastern Himalayas, is of prime interest in the present investigation. Inflammation causes tissue destruction and development of diseases such as asthma, rheumatoid arthritis, and so forth. The ethanolic leaf extract of E. adenophorum (EEA) was administered intravenously and ...

background: hemodialysis patients are at greater risk of cardiovascular disease. higher than expected cardiovascular morbidity and mortality in this population has been attributed to dislipidemia as well as inflammation. the causes of inflammation in hemodialysis patients are multifactorial. several markers were used for the detection of inflammatory reaction in patients with chronic renal dise...

We describe a patient who experienced diffuse, treatment-refractory facial inflammatory reaction following the injection of calcium hydroxylapatite with lidocaine. The was attributed to undiagnosed Hashimoto's thyroiditis. Exogenous thyroid hormone replacement therapy rapidly resolved inflammation associated this type autoimmune hypothyroidism.

Diclofenac sodium has been used for its anti-inflammatory actions for about 28 years, but since all the non-steroidal anti-inflammatory drugs (NSAIDs) suffer from the lethal gastro intestinal (GI) toxicities, diclofenac sodium is not an exception. The free –COOH group is thought to be responsible for the GI toxicity associated with all traditional NSAIDs. In the present research, the main motto...

In sickle cell disease (SCD), the inflammatory properties of high-density lipoprotein (HDL) can be changed by cell-free hemoglobin (Hb), which is released into the blood during hemolysis. Hb in the plasma of SCD patients or mice can bind with HDL specifically inducing an inflammatory reaction. In our study, we found increased amounts of inflammatory factor proteins in the chronic oxidative stat...

Objective: This research was to study the anti-inflammatory and analgesic effects of Climbing Groundsel Herb ethanol extracts. And observe its mechanism of action preliminarily. Methods: HAC writhing reaction and hot plate test were used to observe the analgesic effect of senecio. The mouse ear swelling induced by xylene, the rat granulation tissue hyperplasia induced by cotton ball and rat egg...

Id reaction or autosensitization dermatitis is an acute skin that develops at a site distant from primary inflammatory focus.1,2 It frequently associated with infections. can clinically show various presentations, such as eczematous, urticarial, lichenoid, morbilliform, psoriatic, erythema nodosum and multiforme, rosacea.