INTRODUCTION Lymphedema is a chronic disorder that occurs commonly after lymph node removal for cancer treatment and is characterized by swelling, fibrosis, inflammation, and adipose deposition. Although previous histological studies have investigated inflammatory changes that occur in lymphedema, the precise cellular make up of the inflammatory infiltrate remains unknown. It is also unclear if...

Background: The present study was designed to evaluate the secondary microglial activation processes after spinal cord injury (SCI). Methods: A quantitative histological study was performed to determine ED-1 positive cells, glial cell density, and cavitation size in untreated SCI rats at days 1, 2, and 4, and weeks 1, 2, 3, and 4. Results: The results of glial cell quantification along the 4900...

all-trans retinoic acid (atra), as an active metabolite of vitamin a, has been shown to affect immune cells. this study was performed to evaluate the effect of atra on viability, proliferation, activation and lineage-specific transcription factors of cd4+ t cells. cd4+ t cells were  separated  from  heparinized  blood  of  healthy  donors  and  were  cultured  in conditions, some with, some wit...

This review focuses on methods to image acute lung inflammation with Positron Emission Tomography (PET). Four approaches are discussed that differ for biologic function of the PET reporter probe, radiotracer employed, and specific aspect inflammatory response is targeted. 2-[ 18 F]fluoro-2-deoxy-D-glucose ([ F]FDG) an enzyme substrate whose uptake used measure metabolic activation cells during ...

interleukin-10 (il-10) is a potent immunosuppressor which inhibits alloantigenic t cell response. il-10 is also an anti-inflammatory endogenous cytokine. to investigate the predictive significance of endogenous il-10 for acute graft versus host disease (gvhd) following allogeneic bone marrow transplantation (bmt), we performed a prospective study on spontaneous il-10 production in the serum of ...

Uptake of modified lipoproteins by macrophages results in the formation of foam cells. We investigated how foam cell formation affects the inflammatory response of macrophages. Murine bone marrow-derived macrophages were treated with oxidized LDL (oxLDL) to induce foam cell formation. Subsequently, the foam cells were activated with lipopolysaccharide (LPS), and the expression of lipid metaboli...

The inflammatory response is tightly regulated by several mediators that promote the adhesive and migratory capacities of different cell types, including peripheral blood mononuclear cells (PBMCs). Our laboratory has previously characterized the inflammatory response developed in the experimental model of mercuric chloride (HgCl(2))-induced nephritis in Brown Norway rats as an acute inflammator...