physalis angulata is a medicinal plant used for the treatment of malaria, ulcer, pains and other diverse ailments. the present study evaluated the analgesic and anti-inflammatory activity of methanolic leaf extract of the plant. acetic acid-induced abdominal contraction or writhing analgesic models in swiss albino mice (13-23g) were used for studying analgesic activity of the leaf extract. 200,...

psoriasis is an autoimmune and recurrent chronic inflammatory skin disease. about 1-3% of the world wide populations are affected. the characteristic features are hyperprolifration of keratinocytes leading to redness, thickening and scaling of epidermis followed with itching and appearance of the lesions which in most cases bother the patients medically and psychologically. psoriasis is symptom...

Background and objectives: Drugs with analgesic properties such as opioids and NSAIDs have not been effective in all cases, because of their low potency and side effects. As a result, looking for other alternatives is necessary. Plants are important sources of new phytochemicals that possess significant therapeutic effects. Regarding the traditional use of Artemisia sieberi...

Objective: In cardiovascular diseases, inflammatory response plays an important role and affects heart function. As a flavonoid compound, p-coumaric acid (pCA), commonly exists in many fruits and vegetables and has a therapeutic effect on inflammatory diseases due to its anti-inflammatory properties. The purpose of the present study was to investigate pCA anti-inflammatory effect and the miRNAs...

PURPOSE Long-term consequences of combined pyridostigmine bromide (PB) and permethrin (PER) exposure in C57BL6/J mice using a well-characterized mouse model of exposure to these Gulf War (GW) agents were explored at the protein level. EXPERIMENTAL DESIGN We used orthogonal proteomic approaches to identify pathways that are chronically impacted in the mouse CNS due to semiacute GW agent exposu...

Mol. Nutr. Food Res. 2023, 67, 2200884 DOI: 10.1002/mnfr.202200884 Extracellular Vesicles (EVs) secreted from probiotics are potential EV-based nanomaterials therapy in inflammatory bowel disease (IBD). Clostridium butyricum-derived extracellular vesicles could be a novel agent for treating colitis and colonic miR-199a-3p might serve as therapeutic target IBD. This is reported by Yingping Xiao ...

Xuan-Ju agent is an herbal formula containing aqueous extract of Formica fusca, Herba epimedii, Fructus cnidii, and Fructus lycii, all of which are reputed for their beneficial effects in the treatment of the immunodeficient diseases such as rheumatoid arthritis. We performed a study on the anti-inflammatory effects of this agent using carrageenan- and adjuvant-induced paw edema in rats. Xuan-J...

INTRODUCTION The purpose of this study was to determine the safety, tolerability and effectiveness of daily administration of an orally administered pantothenic acid-based dietary supplement in men and women with facial acne lesions. METHODS A randomized, double-blind, placebo-controlled study of adults previously diagnosed with mild to moderate acne vulgaris was performed. Subjects were rand...

Dapsone 5% gel for the topical treatment for acne vulgaris was recently introduced in Canada. It represents the first new anti-acne agent to gain North American regulatory approval in the past decade. Dapsone's utility is attributable to its anti-inflammatory and antimicrobial properties that improve both inflammatory and non-inflammatory acne, with more prominent effects occurring in inflammat...

The methanolic extract of a macrofungus, P. rimosus possessed significant in vitro superoxide anion, hydroxyl radical and nitric oxide scavenging and lipid peroxidation inhibiting activities. The anti-inflammatory activity of the extract was evaluated in carrageenan and dextran induced acute and formalin induced chronic inflammatory models in mice. The extract showed remarkable anti-inflammator...