The probable antipyretic, antiinflammatory, analgesic and antioxidant properties of Kageneckia oblonga, Rosaceae, were investigated and the major compounds of its active extracts were isolated. The study comprised the acute toxicity of the extracts of global methanol, hexane, dichloromethane and methanol. The cytotoxicity of global methanol extract was studied in three tumoral cell lines. All t...

Background Recent studies revealed that tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis and immune functions within tumor microenvironments. Signal transducer and activator of transcription 3 (STAT3), which is a point of convergence for numerous oncogenic signalling pathways, is constitutively activ...

Averrhoa carambola L., belonging to the Oxalidaceae family is one of popular fruits in Bangladesh. The objective study isolate and purify secondary metabolites from A. leaves investigate phytochemical properties, fatty acid, antioxidant, antimicrobial activity, cytotoxicity both leaves. Phytochemical screening revealed presence lignins, quinones, saponins, flavonoids, phenol, carbohydrates, ste...

Infants with defects in the interleukin 10 receptor (IL10R) develop very early onset inflammatory bowel disease. Whether IL10R regulates lamina propria macrophage function during infant development in mice and whether macrophage-intrinsic IL10R signaling is required to prevent colitis in infancy is unknown. Here we show that although signs of colitis are absent in IL10R-deficient mice during th...

The ethanolic extract leaves of the Cordia myxa plant were used to prepare biosynthesis silvernanoparticles (Ag-NPs). detection Ag-NPs was done using UV, FTIR, and SEM. We evaluated theanti-bacterial property nano against growth two types pathogenic microbes:Gram –ve bacteria (E. coli) Gram +ve (S. aureus). antibacterial activity extractwas high. In vitro, extracts demonstrated strong antioxida...

ABSTRACT: Actinomycetes are one of the important secondary metabolite producers. Researchers focused on exclusive marine areas for isolation and identification actinomycetes. The present study Nocardiopsis dassonovillei (ON627850) from TS Pettai region. potential strainTSP1 showed effective antibacterial activity against Haemophilus influenza. TSP1 isolates IC50 value 75.22 μg/ml antioxidant de...

phytochemical screening, antibacterial and cytotoxic activities of petroselinum crispum leaves grown in oman.petroselinum crispum belongs to the apiaceae family, is a well-known spice and vegetable. the essential oil obtained from the fruit has also strong action on the central nervous system. present study is designed to evaluate the phytochemical screening, antibacterial and cytotoxic activit...

OBJECTIVE Natural killer (NK) cells are understudied in the context of metabolic disease and obesity. The goal of this study was to define the effect of NK cell ablation on systemic inflammation and glucose homeostasis in murine obesity. METHODS A transgenic murine model was used to study the effect of NK cell ablation on systemic inflammation and glucose homeostasis in the context of diet-in...

We previously demonstrated that astaxanthin (ASTX), a xanthophyll carotenoid, repressed ethanol-induced inflammation and oxidative stress in macrophages. explored the role of sirtuin 1 (SIRT1) histone deacetylase 4 (HDAC4) inhibitory effect ASTX on macrophages exposed to ethanol. Ethanol decreased mRNA protein SIRT1 while increasing those HDAC4, which was attenuated by RAW 264.7 mouse bone marr...

Large number of quinones has been associated with antitumor, antibacterial, antimalarial and antifungal activities. In this work we describe the effect of the naphthoquinone, 5-methoxy-3,4-dehydroxanthomegnin, on murine tumor cells (LP07 and LM2) and its immunomodulatory effect on nitric oxide (NO) production on LPS-stimulated macrophages. The results have shown that 5-methoxy-3,4-dehydroxantho...