We aimed to evaluate the efficacy of combination of propranolol and sclerotherapy in treating parotid hemangiomas. Twenty-six parotid hemangiomas patients were subjected to combined treatment from January 2009 and June 2014. The effects of the therapy modality were evaluated. Nineteen patients were females and 7 were males. The median age of treatment initiation was 4.96 months. Twelve lesions ...

Although the gene defects for several mouse mutants with severe osteopetrosis are known, the genes underlying human infantile malignant recessive osteopetrosis remain elusive. Osteopetrosis is thought to be caused by a defect in osteoclast function. These cells degrade bone material in a tightly sealed extracellular compartment that is acidified by a vacuolar (V)-type H(+)-ATPase. Genes encodin...

OBJECTIVE To perform an in depth evaluation of children, and thus provide a systematic method of managing children, who after infantile health screening, were categorized as suspected developmental delay. METHOD 78 children referred to the Developmental Delay Clinic of Ilsan Hospital after suspected development delay on infantile health examinations were enrolled. A team comprised of a physia...

PURPOSE To compare bimedial rectus muscle recession (BMRR; 7-8 mm) and bimedial rectus muscle elongation (BMRE; 6.5-9 mm) for the surgical treatment of large-angle infantile esotropia (ET; ≥70 prism diopters [PD]). PATIENTS AND METHODS Twenty-four patients with large-angle infantile ET were divided into 2 groups; group A (n=12) underwent BMRR and group B (n=12) underwent BMRE. All patients re...

BACKGROUND AND OBJECTIVES Infantile hemangiomas are the most common benign tumor in children. They have 3 phases of development: a proliferative phase, an involuting phase, and involution. Although active treatment is often not required, it is necessary in some cases. Of the possible treatments for hemangiomas, lasers have been shown to be effective in all phases of development. We report our e...

AIM To compare the efficacy of reoperation and botulinum toxin injection in treating infantile esotropes early after unsatisfactory surgical alignment. METHODS 55 strabismic children who had been unsuccessfully operated for infantile esotropia were randomised to reoperation (28 patients) or botulinum toxin injection (27 patients). The motor outcomes (percentage of successful motor outcome and...

Pompe disease is an autosomal recessive disorder and is caused by a deficiency in acid alpha-glucosidase (GAA). A broad range of studies have been performed on Pompe patients from different countries. However, the clinical course and molecular basis of the disease in Mainland China have not been well defined. In the present study, we examined a total of 18 Chinese children with infantile-onset ...

Infantile spasms is an epileptic encephalopathy of early infancy with specific clinical and electroencephalographic (EEG) features, limited treatment options, and a poor prognosis. Efforts to develop improved treatment options have been hindered by the lack of experimental models in which to test prospective therapies. The neuropeptide adrenocorticotropic hormone (ACTH) is effective in many cas...

hemangioma is the most common benign cutaneous vascular tumor in infants and children. the hemangioma incidence in the neonates is 2% to 3% that increases to 10% in those younger than one year of age. before introduction of propranolol in 2008, different medications such as systemic corticosteroids and vincristine, with different side effects, were used for years. since then, over 200 studies c...

the role of enterotoxigenic e.coli as a causative agent in diarrheal disease was studied among 100 cases of infant and children 0-2 years of age. routine bacteriological methods were used for identification enteropathogenic e.coli, salmonella, shigella and vibrio cholera. the ability of e.coli strains to produce toxin was assayed in animal models (rebbit-ileal loop and suckling mice) and in tis...