introduction: despite achievement to complete remission (cr) with current treatments and new multiple chemotherapeutic agents in acute lymphoblastic leukemia (all) patients, the majority of them still relapse during long-term follow-up. the use of post- remission therapy will reduce early relapse in these cases, but the best option is still debatable. patients and methods: in this retrospective...

We report two cases of adult acute lymphoblastic leukemia presenting with preleukemic phase of pancytopenia with a few abnormal lymphoid cells in bone marrow aspirates. The initial diagnosis of each case was suspicious aplastic anemia and hypoplastic anemia. Both cases progressed to overt acute lymphoblastic leukemia within 1 year. We suggest that initial pancytopenic phase (pre-ALL) may preced...

A man with relapsing multiple sclerosis, treated with fingolimod 0.5 mg/d for 15 months, developed acute lymphoblastic leukemia and died 4 months after immune ablation and bone marrow allograft, from graft versus host disease. To our knowledge, this is the first case of acute lymphoblastic leukemia reported in a patient treated with fingolimod. Although no causal relationship can be established...

Multiparametric flow cytometry is an alternative approach to the polymerase chain reaction method for evaluating minimal residual disease in treatment protocols for primary acute lymphoblastic leukemia. Given considerable differences between primary and relapsed acute lymphoblastic leukemia treatment regimens, flow cytometric assessment of minimal residual disease in relapsed leukemia requires ...

The relation between intrauterine growth and risk of childhood acute lymphoblastic leukemia was investigated in an Australian population-based case-control study that included 347 cases and 762 controls aged <15 years recruited from 2003 to 2006. Information on proportion of optimal birth weight, a measure of the appropriateness of fetal growth, was collected from mothers by questionnaire. Data...

We report two cases that presented with unexplained acute renal failure and hyperuricemia and were subsequently diagnosed with T-cell acute lymphoblastic leukemia. The patients improved with conservative therapy without the need for dialysis. Case 1 is the youngest case of acute lymphoblastic leukemia with spontaneous tumor lysis syndrome reported to date, and Case 2 presented with spontaneous ...

INTRODUCTION Osteoporosis in children is rare and usually secondary to an underlying disease process whose diagnosis may be difficult to detect. Etiological factors responsible for osteoporosis secondary to chronic illness include immobility, pubertal delay and other hormonal disturbances. Rarely, it can be a manifestation of acute lymphoblastic leukemia. Most of the reported bone fracture inci...

Tyrosine kinase inhibitors have profoundly modified the treatment and prognosis of chronic myeloid leukemia and Ph(+) acute lymphoblastic leukemia. A rapid and accurate detection of the BCR-ABL fusion protein is paramount today for an optimal management of Ph(+) acute lymphoblastic leukemia. We have utilized a recently described and commercialized immunoassay that identifies qualitatively the p...

background: central nervous system (cns) relapse in acute lymphoblastic leukemia was significantly decreased due to the use of new chemotherapyeutic agents, intrathecal chemotherapy and cranial irradiation. the purpose of this study was to compare the effectiveness of intrathecal (it) cns chemotherapy alone versus combination of it chemotherapy with cranial irradiation for prevention of cns rel...

background: bcl-2 is the most important anti-apoptotic regulator and bax is a pro-apoptotic protein. the status of these parameters or the ration of bcl-2 to bax is important in malignant cell fate as well as normal cells. methods: sixty-two all patients and 62 healthy sex-and age-matched controls were studied. after genotyping, the promoter region of the bax and bcl-2 genes by rflp-pcr method ...