Many immunological defects have been described in HIV disease, including a diminished capacity of naive CD4+ T cells to expand after TCR stimulation. The mechanisms underlying impaired naive CD4+ T cell expansion in HIV disease are not well described. Using a rigorous phenotypic definition of naive T cells, we found that cell cycle entry after TCR engagement was restricted to cells that increas...

Reactive Oxygen Species (ROS) are key mediators of ischemia-reperfusion injury but also required for the induction of the stress response that limits tissue injury and underlies the protection provided by ischemic-preconditioning protocols. Liver steatosis is an important risk factor for liver transplant failure. Liver steatosis is associated with mitochondrial dysfunction and excessive mitocho...

riverbank erosion, land loss and associated sedimentation are river engineering and water resources management problems of global significance. the ability to predict riverbank stability on eroding rivers is the prerequisite of developing a channel width adjustment model and is essential for estimating riverbank erosion and associated sedimentation. in this research, a detailed model for stabil...

The human immunodeficiency virus (HIV) can be suppressed by highly active anti-retroviral therapy (HAART) in the majority of infected patients. Nevertheless, treatment interruptions inevitably result in viral rebounds from persistent, latently infected cells, necessitating lifelong treatment. Virological failure due to resistance development is a frequent event and the major threat to treatment...

BACKGROUND In vivo models of uremia are important tools to study numerous aspects of acute and chronic kidney disease. Mouse models are pivotal because most genetically engineered animal models are mice, which allow dissecting the impact of selected target genes in renal failure. Adenine-based protocols to induce renal failure are available in rats, but have not been adapted in mice due to thei...

This article presents a comparative analysis of the direct torque control with space vector modulation method for seven-phase squirrel-cage induction motor during encoder failure. The model reference adaptive system current and estimator system—flux based applied in loop speed have been analyzed. mathematical system-type estimators described. to voltage source inverter, controlled motor, has op...

BACKGROUND Following abdominal solid organ transplant (aSOT), valganciclovir (VGC) is recommended for cytomegalovirus (CMV) prophylaxis. This agent is associated with efficacy concerns, toxicity, and emergence of ganciclovir resistance. OBJECTIVE To evaluate the incidence of high-dose acyclovir (HD-A) prophylaxis failure in seropositive aSOT recipients (R+). METHODS This was a retrospective...

AIMS Despite increased understanding of the fundamental biology regulating cardiomyocyte hypertrophy and heart failure, it has been challenging to find novel chemical or genetic modifiers of these pathways. Traditional cell-based methods do not model the complexity of an intact cardiovascular system and mammalian models are not readily adaptable to chemical or genetic screens. Our objective was...

BACKGROUND Successful cesarean delivery anesthesia has been reported with use of small doses (5-9 mg) of intrathecal bupivacaine coadministered with opioids. This double-blind, randomized, dose-ranging study determined the ED50 and ED95 of intrathecal bupivacaine (with adjuvant opioids) for cesarean delivery anesthesia. METHODS Forty-two parturients undergoing elective cesarean delivery with ...

corneal transplantation is the most common and successful form of solid organ transplantation with a 2-year survival rate of over 90% in low risk cases. this high success rate may be due to the immune privileged status of the cornea, acaid (anterior chamber associated immune deviation) induction phenomena and secretion of inhibitory molecules by corneal cells such as il1-ra, il-1a and fas ligan...