objective: diabetes is a metabolic disorder which impairs carbohydrate and lipid metabolism. it is accompanied by cognition impairment in diabetic patients and animal models. lipids play an important role in nerve membrane composition, structure and function. this study was designed to evaluate the effect of dietary butter and sesame oils on passive avoidance memory of streptozotocin (stz) diab...

cardiac disorders remain one of the most important causes of death in the world. oxidative stress has been suggested as one of the molecular mechanisms involved in drug-induced cardiac toxicity. recently, several natural products have been utilized in different studies with the aim to protect the progression of oxidative stress-induced cardiac disorders. there is a large body of evidence that a...

Considerable effort has been directed at understanding the nature of the communicative deficits observed in individuals with acquired brain injuries. Yet several theoretical, methodological, and clinical challenges remain. In this article, we examine distributed cognition as a framework for understanding interaction among communication partners, interaction of communication and cognition, and i...

Stress resulting from living in large cities (and alienation in certain individuals) fuels the high incidence of psychiatric illnesses in modern metropolises. Some pathology as Schizophrenia and Asperger has deficits on social cognition mechanisms and its presentation may be influenced by social environmental impact. Even more, common mental disease such as depression and personality disorders ...

Introduction:Cholesterol has different effects on memory, and diabetes caused adverse effect on cognition. Since there is not enough evidence regarding the effect of cholesterol on memory of diabetic animals, the effects of cholesterol and simvastatin on the passive avoidance memory of diabetic rat were studied. Methods:The study was done on 60 male Wistar rats (180 ± 20g). Diabetes was in...

BACKGROUND/AIMS Cognitive impairment is a well-established correlate of psychotic symptoms in Alzheimer's disease (AD-P). We review whether this relationship has confounded previous genetic association studies of 5HTTLPR and AD-P. METHODS We reviewed all studies on 5HTTLPR and conducted a semi-quantitative analysis. RESULTS Three out of 4 studies with low MMSE reported a significant associa...

BACKGROUND Longitudinal reports on the clinical features of patients with Alzheimer's disease (AD) and concomitant cerebrovascular disease are scarce. METHODS We elaborated a working definition of AD with vascular component (ADVC), and this definition was retrospectively investigated in a cohort of patients with cognitive deterioration who were prescribed a cholinesterase inhibitor during usu...

OBJECTIVE Large epidemiological surveys conducted in the developed world have found rates of psychotic symptoms in the general population to be as high as 10-28%. However, there are few data available from developing countries, including African countries, on the prevalence and correlates of psychotic symptoms. This study investigates the prevalence and correlates of psychotic symptoms (ie hall...

We conducted a meta-analysis using all available controlled treatment outcome studies of cognitive therapy (CT) for psychotic symptoms in schizophrenia. Effect sizes were calculated for seven studies involving 340 subjects. The mean effect size for reduction of psychotic symptoms was 0.65. The findings suggest that cognitive therapy is an effective treatment for patients with schizophrenia who ...

Compliance and relapse are major issues in the treatment of psychotic disorders. About 50% of subjects with schizophrenia do not comply with treatment and relapse rates of 65% are reported after one year and 80% after two years. Drug treatments are effective against psychotic symptoms, but cannot promote functional recovery or prevent relapses when prescribed alone. The factors influencing comp...