mast cells play an important role in a variety of inflammatory diseases, particularly asthma and atopy. peroxisome proliferator-activated receptor gamma (pparγ) is a member of the large nuclear hormone  receptor  transcription  factor  superfamily, and  has  been  recently implicated in the anti-inflammatory response. to investigate a possible role for pparγ in human mast cells, we studied the ...

this descriptive study was conducted to determine the prevalence of asthma and related symptoms among 6-7 and 13-14 year old school children in tehran as a part of international study of asthma and allergies in childhood (isaac) phase iii. the isaac written questionnaire was given to a total of 6127 students of 72 schools in urban area of tehran. simple random sampling was performed with a unif...

the process of bronchial tissue repair/remodeling depends on balance between production and degradation achieves the regulation of extracellular matrix turnover. we designed this study to evaluate relation between transforming growth factor β1 (tgfβ1) and tissue inhibitory of metaloproteinase 2 (timp2) as two main tissue mediators on activity and reversibility of asthma and chronic obstructive ...

Exposure to ozone, which is a major component of air pollution, induces a form of asthma that occurs in the absence of adaptive immunity. Although ozone-induced asthma is characterized by airway neutrophilia, and not eosinophilia, it is nevertheless associated with airway hyperreactivity (AHR), which is a cardinal feature of asthma. Because AHR induced by allergens requires the presence of natu...

BACKGROUND/AIMS Regulatory T cells (Treg) are critical regulators of asthma. Crocetin is isolated from Chinese herb saffron and is a natural carotenoid dicarboxylic acid with anti-inflammatory potential. However, the effects of Crocetin on asthma as well as the underlying mechanisms have not been studied. METHODS We used Crocetin to treat mice with established ovalbumin (OVA)-induced asthma. ...

Asthma is one of the most common respiratory manifestations in children and sometimes is provoked by food allergens with two mechanisms: ingestion or inhalation Clinical evidence acquired in recent years shows that the role of foods in asthma is far from being clear, while food allergy (FA) is well known as one of the leading causes of atopic disease. FA-induced manifestations range from urtica...

OBJECTIVES The aim of this study was to evaluate the coexisting factors and usefulness of diagnostic methods in metal-induced asthma in Polish welders. MATERIALS AND METHODS Examination of 50 welders occupationally exposed to metals and with suspicion of metal-induced asthma (group A), 100 welders occupationally exposed to metals but without suspicion of metal-induced asthma (group B), and tw...

BACKGROUND Little information is available regarding eosinophil activation and cytokine profiles in relation to age in virus-induced bronchial asthma. We therefore explored the association between age, respiratory viruses, serum eosinophil cationic protein (ECP), and cytokines/chemokines in acute exacerbations of childhood asthma. METHODS We investigated viruses in nasal secretions from 88 pa...