OPERATION of a nervous mechanism in the genesis of cardiac arrhythmias secondary to the injection of calcium chloride was suggested by the observation that electrical sympathetic stimulation consistently induced ventricular arrhythmias only when calcium chloride was given simultaneously. Insight into the problem was obtained when sympatholytic and other autonomic blocking drugs were reported to...

The clinical significance of rapid self-terminating ventricular tachycardia induced during electrophysiologic study was prospectively evaluated in three patient groups with clinical ventricular arrhythmias. Group A (11 patients) had inducible rapid self-terminating ventricular tachycardia only (mean cycle length less than or equal to 250 ms and greater than or equal to 10 beats in duration). In...

Wacker, Michael J., Shaun R. Best, Lisa M. Kosloski, Christopher J. Stachura, Rory L. Smoot, Charles B. Porter, and James A. Orr. Thromboxane A2-induced arrhythmias in the anesthetized rabbit. Am J Physiol Heart Circ Physiol 290: H1353–H1361, 2006. First published December 9, 2005; doi:10.1152/ajpheart.00930.2005.—Experiments were conducted in the anesthetized rabbit to investigate mechanisms f...

The effect on cardiac rhythm of the fall in plasma potassium concentration induced by nebulised beta2-agonist therapy was studied in 20 patients admitted to hospital with an acute exacerbation of their reversible chronic airflow limitation. Arrhythmias considered serious or potentially life-threatening were recorded in 13 patients (65%). However, there was no significant increase in these arrhy...

Changes in the normal rhythmicity of a human heart may result in different cardiac arrhythmias, which may be immediately fatal or cause irreparable damage to the heart when sustained over long periods of time. The ability to automatically identify arrhythmias from ECG recordings is important for clinical diagnosis and treatment, as well as, for understanding the electrophysiological mechanisms ...

The proposal that thiazide diuretics may increase cardiovascular risk receives no support from recent data. Current evidence does not indicate that diuretic-induced hypokalaemia is associated with increased ventricular arrhythmias. This evidence includes continuous electrocardiographic monitoring--which is the most sensitive technique for quantitating cardiac arrhythmias. In contrast to earlier...

Tachycardia is common in the pediatric age group. The most commonly seen arrhythmias in children are sinus tachycardia. However, supraventricular tachycardia is the most common tachyarrhythmia that necessitates treatment. Ventricular tachycardia is rare in healthy children but may be associated with sudden cardiac death.  The important risk factors that predispose children for arrhythmias inclu...

Background. We recently reported that sodium channel block can produce opposite effects on action potential duration (APD) and refractoriness in epicardial versus endocardial tissues of the canine ventricle. In addition, strong sodium channel current inhibition was found to cause loss of the action potential dome in epicardium but not endocardium, thus inducing a marked dispersion of repolariza...

RATIONALE Although ventricular premature beats (VPBs) during acute regional ischemia have been linked to mechanical stretch of ischemic tissue, whether and how ischemia-induced mechanical dysfunction can induce VPBs and facilitate their degradation into reentrant arrhythmias has not been yet addressed. OBJECTIVE This study used a novel multiscale electromechanical model of the rabbit ventricl...