Purpose: To investigate Curcuma longa Linn against neuronal damage induced by exposure to sevoflurane during surgical procedures.
 Methods: A sealed box made of transparent glass was used for anaesthetic neurons. The neurons were exposed at doses 1.5, 3, 6 and 12 μM prior viability assessment using MTT assay. effect treatment on protein expression determined western blotting.
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Introduction: Previous studies have proven that secretory materials of mesenchymal stem cells (MSCs) (secretome) remedial properties. Objectives: The main goal this study was to evaluate the effects secretome adipose-derived MSCs on growth and apoptosis in anaplastic thyroid carcinoma (ATC) C-643 cells. Materials Methods: Initially, were exposed 25 50 μg/mL (ADSCs) for 24 48 hours, proliferatio...

In this study, the antioxidative effect of melatonin was investigated in aging retinal pigment epithelial cells vitro. The objective study is to explore administration pharmacological doses for prevention symptoms.Specific concentrations (20 µM, 40 µM and 80 µM) were used treat hydrogen peroxide-induced flow cytometry employed examine cell apoptosis. A specific probe utilized detect intracellul...

Metformin has been used to treat cases of type 2 diabetes mellitus, and mounting studies have shown that metformin can act alone or in synergy with other anticancer agents achieve anti-cancer efficacies on various types tumors. However, the role either inducing autophagy cisplatin-resistance human gastric cancer (GC) cells never examined. The study established a cisplatin-resistant GC cell line...

Background and Objective: Rheum turkestanicum (R. turkestanicum) has been known to reduce inflammation and has antioxidant properties such as protective effect in neurons. This study aimed to determine the effects of R. turkestanicum on neuronal toxicity induced by the pro-parkinsonian neurotoxin 6-hydroxydopamine (6-OHDA) in neuroblastoma SH-SY5Y cells. Materials and Methods: MTT and DNA frag...

Objective(s): To analyze the potential influences of propofol on the oxidative stress of H2O2-induced human esophageal squamous cell carcinoma (ESCC) Eca109 cell through mediating the Wnt/β-catenin signaling pathway.Materials and Methods: Eca109 cells were classified into 5 groups: Control group, H2O2 group, Propofol + H2O2 group, Dkk1 (Dickkopf-1, Wnt/β-catenin pathway antagonist) + H2O2 group...

Abstract Objective Chondrocyte apoptosis plays a vital role in osteoarthritis (OA) progression. Angelica sinensis polysaccharide (ASP), traditional Chinese medicine, possesses anti-inflammatory and anti-apoptotic properties chondrocytes. This study aimed to determine the protective of ASP on sodium nitroprusside (SNP)-induced chondrocyte apoptosis, explore underlying mechanism. Method Human pri...

background: our previous studies revealed an inhibitory effect of icd-85 (venom derived peptides) on mda-mb231 and hl-60 cell lines, through induction of apoptosis. the purpose of this study was to investigate apoptosis-induced mechanism on hela and mrc-5 cells by icd-85 through activation of caspase-8. methods: cell viability, cytosolic enzyme lactate dehydrogenase (ldh) and cell morphology we...

background: interfering with cell proliferation and survival is a critical role for antineoplastic drugs leading to cell death through induction of apoptosis. alternative treatments with herbal extracts offer insights into acute myeloid leukemia (aml) therapy. parthenolide (ptl), an extract from feverfew, induces apoptosis in primary human leukemia stem cells (lscs) and bulk leukemic cell popul...

Abstract Background Alcohol-induced intestinal dysbiosis disrupts and inflammatory responses are essential in the development of alcoholic fatty liver disease (AFLD). Here, we investigated effects Fmo5 on changes enteric microbiome composition a model AFLD dissected pathogenic role AFLD-induced pathology. Methods The expression profile data GSE8006 GSE40334 datasets were downloaded from GEO dat...