background & aim:  non-steroidal anti-inflammatory drugs (nsaids) are commonly used in clinical medicine. the adverse effects they produce in the gastrointestinal tract however, often limit their utility. oxidative stress has been shown to occur in the small intestine in response to the oral administration of indomethacin. in view of this, the effect of thyme essential oil, an agent with an...

objective : the study evaluated the efficacy and safety of vaginal rogesterone on prevention of recurrent preterm labor. materials and methods: total number of 70 patients with preterm labor treated with intravenous magnesium sulfate in perinatology department of valiasr hospital entered to a randomized clinical trial. treatment group after inhibition of preterm labor with magnesium sulfate rec...

BACKGROUND A new formulation of olanzapine available for terminally ill patients is needed. Rectal administration using suppositories is an alternative for patients for whom administration via the oral route is not feasible. In the present study, we prepared olanzapine suppositories, and confirmed using pharmaceutical tests. Furthermore, we demonstrated the efficacy and safety of olanzapine sup...

background: data suggest that v. arctostaphylos, b. thunbergii var. atropurpurea, e. angustifolia and l. acanthodes may prevent gastric ulcers induced by non-steroidal anti-inflammatory drugs (nsaids). objective: to explore the ulcer-protective potential of these plants in indomethacin-induced gastric ulcers in rats. methods: saline, hydro-alcoholic extract of each plant (100, 400, 800 mg/kg) a...

Let JL be a positive Borel measure with support supp JL = E C -1,1) and let

Background & aim:  Menopause is one of the most critical stages in a woman’s life. Special attention needs to be paid to the quality of life of menopausal women. Symptoms of genitourinary atrophy can affect women’s comfort and quality of life. The aim of this study was to compare two treatment methods of vitamin E suppository and conjugated estrogens vaginal cream on the quality of life of meno...

the leukotrienes and prostaglandins are biologically active metabolites derived from arachidonic acid. the leukotrienes have a role in inflammatory diseases such as allergic rhinitis, inflammatory bowel disease and asthma. montelukast, a cysteinyl leukotriene receptor antagonist, is claimed to be effective in asthma. the present study aimed to assess the role of cysteinyl leukotriene receptor a...

intraventricularhemorrhage (ivh) is one of thecommon morbidities among preterm neonates. in thepresentstudy, we set out to evaluate the efficacy of two prophylactic modalities (ibuprofen and indomethacin prophylaxis) for prevention of ivh in our local setting. a prospective study was carried out in akbar-abadi hospital, tehran-iran (2013-2014). ninety-six preterm neonates who cared in closed in...

objective(s) the purpose of the present study was to use the solid dispersion (sd) technique to improve the dissolution rates of indomethacin (imc). materials and methods imc solid dispersions in pvp k30 and isomalt (galen iq 990) were prepared using the solvent evaporation technique and a hot melt method in weight ratios of 2, 10 and 30% (imc:pvp). solid dispersions and physical mixtures were ...