BACKGROUND AND OBJECTIVES   The present study was conducted to investigate the possible gastroprotective effect of sildenafil citrate, a selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase, against indomethacin-induced gastric damage in rats. Further, the study was extended to investigate some possible mechanisms underlying this effect. MATERIALS AND METHODS Forty...

Cymbopogon citratus is a medicinal plant popularly used in Brazil for the treatment of various diseases, and the research interest in this plant is justifiable because of its potential medicinal value in stomachache and gastric ulcer. This study was aimed to test the validity of this practice by using experimental models of gastric ulcer and to clarify the mechanisms of gastroprotection by C. c...

Pongamia pinnata has long been used in folk medicine in treatment for bronchitis, whooping cough, rheumatic arthritis, and diabetes, various inflammatory conditions and dyspepsia. Therefore, Present study was designed to investigate the antiulcer effect of hydroalcoholic extract of leaves of P. pinnata (HLEPP) using different models of gastric ulceration in rats. Hydroalcoholic extract of leave...

background & aim:  non-steroidal anti-inflammatory drugs (nsaids) are commonly used in clinical medicine. the adverse effects they produce in the gastrointestinal tract however, often limit their utility. oxidative stress has been shown to occur in the small intestine in response to the oral administration of indomethacin. in view of this, the effect of thyme essential oil, an agent with an...

Management of the gastric toxicity of non-steroidal anti-inflammatory drugs (NSAIDs) remains a crucial problem because the commercially available drugs have side effects and are often expensive. Therefore, we examined the potential of the green tea-derived polyphenol epigallocatechin gallate (EGCG) to treat indomethacin-induced stomach ulcers in mice. Administration of indomethacin (18 mg/kg, p...

Cupressus sempervirens (C. sempervirens) belongs to the family Cupressaceae. It is widspread in Northern Africa, Greece, Turkey, North America, Cyprus and Syria. Cupressuflavone is the major ingredient of the plant leave extract. The aim of the present study was to evaluate the antiulcerogenic activity of the extract of C. sempervirens leaves in gastric ulcer tissues induced by indomethacin. Th...

The results of earlier studies by my team of researchers demonstrated the wide spectrum of in vivo gastro-protective effects of the methanol extract of Cassia singueana leaves (MECSL) in rats. The crude extract exhibited profound potency against experimentally-induced ulcerative lesions in various gastric ulcer induction models (pyloric ligation/histamine, indomethacin and ethanol-mediated stom...