Author Affiliations: 1 Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda 2 Microbiome Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota 3 Department of Surgery, Mayo Clinic, Rochester, Minnesota 4 Health Sciences Research, Mayo Clinic, Rochester, Minnesota 5 Department of P...

Management of high-risk hip fracture patients is complicated. The optimal surgical decision must be individualized and made promptly, with the assistance of all important team members, including primary care doctors, patient, family, and the orthopedic team. The risks of delaying surgery are significant and should be avoided if possible. Strategies for improving outcomes in these patients inclu...

Anterior cruciate ligament (ACL) reconstruction surgery has significantly evolved in recent years. This has led to development of new technologies that facilitate the diagnosis of ACL injury and the application of state of the art methods for treatment. In particular, individualized anatomical ACL reconstruction aims to restore native ACL function. Treatment is tailored to each patient based on...

The contribution of 68Ga to the promotion and expansion of clinical research and routine positron emission tomography (PET) for earlier better diagnostics and individualized medicine is considerable. The potential applications of 68Ga-comprising imaging agents include targeted, pre-targeted and non-targeted imaging. This review discusses the key aspects of the production of 68Ga and 68Ga-based ...

Genetic variations have been shown to influence drug metabolism, risk of adverse drug events, and pharmacodynamic responses for many drugs routinely used to treat patients with stroke or at risk for stroke. Examples include clopidogrel, statins, antihypertensive medications, and coumadin. Further validation studies are needed to assess the clinical utility of selecting drugs and doses based on ...

Division for Cardiothoracic-, Transplantation& Vascular Surgery, Hannover Medical School, Hannover, Germany Center of Competence for Cardiovascular Implants – Medimplant, Hannover Medical School, Carl-NeubergStraße 1, 30625 Hannover, Germany *Author for correspondence: Tel.: +49 511 532 6592; Fax: +49 511 532 5404; wilhelmi.mathias@mh-hannover.de “...medical implants in the era of personalized ...

A multitude of noninvasive, quantitative, functional imaging techniques are currently in use to study tumor physiology, to probe tumor molecular processes, and to study tumor molecules and metabolites in vitro and in vivo using computed tomography (CT), magnetic resonance imaging (MRI), ultrasonography (US), positron emission tomography (PET), single-photon emission computed tomography (SPECT),...

The past decade has seen an escalating enthusiasm to comprehend chronic tinnitus from the perspective of both scientific understanding and clinical management. At the same time, there is a significant interest and commercial investment in providing targeted and individualized approaches to care, which incorporate novel sound-based technologies, with standard audiological and psychological strat...

Nanomedicine is a reality of medical research and clinical practice, and it offers new and promising approaches to fundamental problems in medicine. Most prominent are the early detection of neoplastic disease and the individualized treatment of metastases. These potentially transformational developments require careful scrutiny of the potential impact of nanomedicine on society, so that the co...