Indandione 1 was brominated to yield 2-bromoIndandione 2 which on further reacted with substituted thiocarbamides, carbamides, 2-aminothiophenols, 2-aminophenol and triazoles to furnished 3-substituted aniline-2-thia-4-aza-6,7-benzo-8-oxo-bicyclo [3.3.0]-1(5),3-octadiene 3, 3-substituted aniline-2-oxa-4-aza-6,7-benzo-8-oxo-bicyclo [3.3.0]-1(5),3-octadiene 4, 2-Thia-5-aza-9-oxo-3,4-(3’-substitut...

the ir and nmr spectra were coupled with quantum chemical calculations in dft approach usingthe hybrid b3lyp exchange-correlation functional to confirm the structure of 2-methoxycarbonyl-7-methyl-1,3-thiazino[3,2-b][1,2,4]triazine-4,8-dione 2d.

6-((2-(Dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)-quinolin-7-one dihydrochloride (TAS-103) is a quinoline derivative that displays antitumor activity in murine and human tumor models. TAS-103 has been reported to be a potent topoisomerase II poison. However, other studies have indicated that cellular susceptibility to TAS-103 is not correlated with topoisomerase II expression. Becaus...

The title mol-ecule, C(13)H(11)NO(3), a natural compound extracted from Phellodendron chinense, exhibits a near planar framework: the mean deviations from the furo[2,3-b]quinoline ring system and from the whole mol-ecule (not including the H atoms) are 0.006 and 0.062 Å, respectively.

Pyranoquinoline alkaloids, which possess inter­ esting pharmacological properties are known [1, 2] to occur in the plant family Rutaceae. The alka­ loids, khaplofoline (1) and ribalinine (2), isolated respectively from Haplophyllum foliosum (Vved) [3] and Balfourodendron riedelianum [4], members of the rutaceae, are structurally proven to be of pyrano [2,3-b]quinoline systems. Several reports h...

In the cation of the title salt, C(12)H(14)N(3)O(+)·C(24)H(20)B(-), the dihedral angle between the quinoline ring and the mean plane of the urea fragment is 61.51 (5)°. In the crystal, the cations inter-act through weak C-H⋯O hydrogen bonding, forming a zigzag chain along the c-axis direction; the cations and anions are involved in weak inter-molecular C-H⋯π and N-H⋯π inter-actions as donors an...

The Pd(II) ion in the title complex, [PdBr(2)(C(18)H(12)N(2))], is four-coordinated in a distorted square-planar environment by the two N atoms from the chelating 2,2'-biquinoline (Biqu) ligand and two mutually cis Br(-) anions. The Biqu ligand is not planar, the dihedral angle between the quinoline systems being 17.2 (2)°. In the crystal, the complex mol-ecules are connected by C-H⋯Br hydrogen...

Polycyclic aromatic hydrocarbons (PAHs) are tobacco carcinogens implicated in the causation of human lung cancer. Metabolic activation is a key prerequisite for PAHs to cause their deleterious effects. Using human lung adenocarcinoma (A549) cells, we provide evidence for the metabolic activation of (+/-)-trans-7,8dihydroxy-7,8-dihydrobenzo[a]pyrene (B[a]P-7,8-trans-dihydrodiol) by aldo-keto red...