Introduction: The aim of the study was to evaluate the sustained release effect of 2% chlorhexidine and its combination with 2% chitosan, in vitro. Method: The sustained release effect of chlorhexidine and its combination with chitosan was determined using a UV spectrophotometer. Results: UV spectrophotometer analysis for the sustained release of chlorhexidine showed that almost 100% of chlorhe...

The review examines the relationship between the structure of several ryanodine analogs and (A) binding, (B) channel conductance, and (C) ligand binding kinetics. Comparative molecular field analysis (CoMFA) and comparative molecular similarity analysis (CoMSIA) are used to quantitatively assign structural correlations. Hydrogen bond donating (but not accepting) ability was found to be highly c...

The in vitro interaction of the [65]and [6Ä]-stereoisomers of CHO-THFA with human RBCs was investigated in the (therapeutically comparable) concentration range from 1.0 to 12.5 ng/ml. Both compounds are bound to RBCs with a kRBC ranging from 0.13 to 0.75 for [65]-CHO-THFA and from 0.06 to 0.33 for [6/?]-CHO-THFA, respectively. The interaction of the [65]-form with RBCs is about two times higher...

The present investigation deals with the development of controlled release tablets of salbutamol sulphate using graft copolymers (St-g-PMMA and Ast-g-PMMA) of starch and acetylated starch. Drug excipient compatibility was spectroscopically analyzed via FT-IR, which confirmed no interaction between drug and other excipients. Formulations were evaluated for physical characteristics like hardness,...

The objective of research was to explore the suitability of lipids like compritol 888 ATO and stearic acid as release retardant to develop sustained release (SR) tablets. The SR micromatrices of lipid (s) and glipizide were prepared (LM1- LM6) as intermediate product by fusion method and assessed for various pharmacotechnical properties. Micromatrices were formulated as SR tablets (F1-F6) by di...