background: acute promyelocytic leukemia (apl) is a subclass of acute myeloid leukemia. the chromosomal aberration in 95% of apl cases is t(15; 17) (q22; q21), which prevents cell differentiation. characterization of the underlying molecular lesion is valuable in determining optimal treatment strategy. the goal of this study was to develop a new and powerful flow- fish technique to detect the l...

purpose : to assess and to compare stromal and endothelial changes at the cellular level in patients who had photorefractive keratectomy (prk) and laser in situ keratomileusis (lasik) using in vivo confocal microscopy methods : in this semiexperimental study, 32 eyes of 16 patients (4 males and 12 females) with low to moderate myopia [-1.00 to -4.50 diopters (d)] or low to moderate myopic astig...

atom transfer radical polymerization of styrene (st) and methyl methacrylate (mma) was performed at 90oc in the absence and presence of nanoclay (cloisite 30b). trichloromethyl-terminated poly(vinyl acetate) telomerand cucl/ pmdeta were used as a macroinitiator and catalyst system, respectively. the experimental results showed that the atom transfer radical polymerization of st and mma in the a...

Alginate films with different degrees of crosslinking obtained by internal and external gelation method and alginate films incorporated with oregano essential oil were prepared. The effect of mechanism of gelation and the incorporation of oregano essential oil on their optical, mechanical, antibacterial, microstructural and water vapor barrier properties were evaluated. The films subjected to e...

The mechanism by which native silk feedstocks are converted to solid fibres in nature has attracted much interest. To address this question, the present work used rheology to investigate the gelation of Bombyx mori native silk feedstock. Exceeding a critical shear stress appeared to be more important than shear rate, during flow-induced initiation. Compositional changes (salts, pH etc.,) were n...

high purity fluorapatite (FA) with rod-like and spherical-like morphology was synthesized via sol-gel method. Chemical characterization of FA powders was done by XRD and FTIR analyses. Crystallite samples were calculated using Scherer method. Morphology of FA powders was investigated with TEM and SEM images. The results revealed that increasing the time of hydrolysis of phosphate sols significa...

We report the preparation of a hybrid chitosan/silica three-dimensional (3D) scaffold loaded simultaneously with two model hydrophilic substances, ibuprofen sodium salt and erioglaucine disodium salt. The first substance is entrapped in situ during chitosan submillimetric beads by ionotropic gelation triphosphate, while latter post-loaded formation. Controlled release experiments carried out un...

The objective of this work was to develop an oral mucosal drug delivery system to facilitate the local and systemic delivery of acyclovir for the treatment of oral herpes infection caused by the herpes simplex virus (HSV). An in situ gelling system was used to increase the residence time and thus the bioavailability of acyclovir in oral mucosa. Temperature and pH trigged in situ gel formulation...

In-situ forming polymeric gelling systems has become prominent among novel drug delivery system (NDDS) in recent years due to advantages such as sustained and prolonged drug action, improved patient compliance and reduced frequency of administration of the drug in comparison to conventional drug delivery system (DDS). This is a type of mucoadhesive DDS where the polymeric formulation is in sol ...

The purpose of this study was to develop pluronic-based in situ gelling formulations of metronidazole (MTZ) for treatment of bacterial vaginosis, aimed at prolonging the residence time, controlling drug release, enhancing efficacy, decreasing recurrence, and increasing patient compliance. The in situ gel formulations were prepared using different concentrations of pluronic F-127 (PF-127) alone ...