Some biologically active compounds isolated from sea cucumbers stimulate the body’s immune response by activating cells. Immune function is closely related to integrity intestinal barrier and balanced gut microbiota. However, it unknown whether daily administration of holothurian wall hydrolysate (HWH) ameliorated dysbiosis injury induced immunodeficiency. This study aimed investigate immunomod...

Realization of the full potential of immune checkpoint inhibitor-targeted onco-immunotherapy is largely dependent on overcoming the obstacles presented by the resistance of some cancers, as well as on reducing the high frequency of immune-related adverse events (IRAEs) associated with this type of immunotherapy. With the exception of combining therapeutic monoclonal antibodies, which target dif...

For the problem of indeterminate direction of local search, lacking of efficient regulation mechanism between local search and global search and regenerating new antibodies randomly in the original optimization version of artificial immune network (opt-aiNet), this paper puts forward a novel predication based immune network (PiNet) to solve multimodal function optimization more efficiently, acc...

Background Many attempts have been made to improve human body resistance towards infection. These attempts were exemplified by promotion of hygiene and the use of antiseptic ingredients, pharmaceutical compounds, and vaccines. To prove an aspect which intentionally less explored was attempt to boosting the host immune responses by creating a psychological balance, which was important aspect of ...

The surface marker profile of mesenchymal stromal cells (MSCs) suggests that they can escape detection by the immune system of an allogeneic host. This could be an optimal strategy for bone regeneration applications, where off-the-shelf cells could be implanted to heal bone defects. However, it is unknown how pre-differentiation of MSCs to an osteogenic lineage, a means of improving bone format...