BACKGROUND AND AIMS In a previous report, we characterized a condition of gluten sensitivity in juvenile rhesus macaques that is similar in many respects to the human condition of gluten sensitivity, celiac disease. This animal model of gluten sensitivity may therefore be useful toward studying both the pathogenesis and the treatment of celiac disease. Here, we perform two pilot experiments to ...

Microbial growth in moisture-damaged buildings is associated with respiratory and other symptoms in the occupants. Streptomyces spp. are frequently isolated from such buildings. In the present study, we evaluated the responses of mice after repeated exposure to spores of Streptomyces californicus. Mice were exposed via intratracheal instillation to six doses (at 7-day intervals) of the spores o...

studies have shown that aflatoxin is immunosuppressive and its ingestion in feed has resulted in decreased immunity in vaccinated birds .therefore, the purpose of the present study was to determine the efficacy of sodium bentonite (sb) and esterified glucomannan (e-gm) of yeast cell wall, in counteracting the toxic effects of aflatoxin (af) on immunization against infectious bursal disease (ibd...

An increasing aim in safety assessment of chemicals and drugs is to reduce, refine and replace animal testing, especially in the context of the new system for the registration, evaluation and authorisation of chemicals (REACH). Regarding immunosuppression, most methods are based on mitogen stimulation assays. To our knowledge the in vitro antibody response (Mishell-Dutton culture) has never bee...

Submit Manuscript | http://medcraveonline.com Abbreviations: LCT: Lambda-Cyhalothrin; LD: Lethal Dose; NOAEL: No-Observed-Adverse-Effect Level; Con A: Concanavalin A; SRBCs: Sheep Red Blood Cells; WBCs: White Blood Cells; Ig: Immunoglobulin; HA: Hemagglutination; QHS: Quantitative Hemolysis of SRBCs; FCS: Fetal Calf Serum; DTH: Delayed-type of Hypersensitivity Response; BMCs: Blood Mononuclear ...

Abstract Several FDA-approved adjuvant formulations, such as saponins and lipid nanoparticles, have been shown to mediate their effects in part through the NLRP3 inflammasome. These formulations are among most potent adjuvants use, but they limited by poor synthetic control immunotoxic side effects. New small molecule targeting inflammasome would allow broader implementation of subunit- nucleot...

Three neurodegenerative disorders- Alzheimer’s dementia (ALZ), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS)- share a common feature in their pathogenesis: evidence of mitochondrial dysfunction reactive oxygen stress. Their pathologic classifications are based on the findings at autopsy patterns protein aggregates neurons glial cells. This pathology supports concept that neur...

Copyright © 2012 Elke Dopp et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Biomethylation of metals and metalloids is a process ubiquitously occurring in the environment (under aerobic and anaerobic conditions), which leads...