We present an interesting case of pemphigus vulgaris with severe and rare eye manifestations. An old lady with systemic and ocular manifestations of pemphigus vulgaris was treated with systemic corticosteroids and immunosuppressants, with no effect. Subconjunctival injection of triamcinolone acetate reduced the ocular signs and led to gradual reduction of the systemic medications.

Theprognosis for patients with systemic lupus erythematosus (SLE) has improved over the past several decades (1). In some studies, 10-year survival estimates of >90%have been reported. This improvement has likely been the result of more judicious use of immunosuppressive medications including corticosteroids and immunosuppressants and the availability of better treatment for the organ damage th...

Alcohol / Ammonia Antibiotics Bile Acids Biogenic Amines Blood Gases BNP Co-oximetry CSF Endocrine General Serum Chemistry General Therapeutic Drugs Glycohaemoglobin IGF-1 / C Peptide Immunosuppressants Near Patient Testing (POC) Neonatal Bilirubin Plasma Metanephrines Porphyrins Special Lipids Special Therapeutic Drugs Sweat Electrolytes Trace Elements Tumour Markers Urine Chemistry Urine Preg...

The immunosuppressants tacrolimus (FK506) and cyclosporine A inhibit calcineurin and have potent antifungal activity. In this study, 24% of Cryptococcus neoformans isolates from solid-organ transplant patients exhibited altered sensitivity to these drugs, which may have an impact on the infectious course but does not appear to be the consequence of immunosuppressive therapy.

We report on a case of diffuse alveolar haemorrhage in a Chinese woman due to methimazole-induced antineutrophil cytoplasmic antibodies. A literature search for anti-thyroid drugs associated with antineutrophil cytoplasmic antibody-induced diffuse alveolar haemorrhages is reviewed. Diffuse alveolar haemorrhage is a rare complication of thiourea agents and the treatment often requires corticoste...

The use of MMF has become standard practice in many solid organ transplant recipients due its efficacy and favorable risk profile compared to other immunosuppressants. There has been a single case report of successful MMF desensitization. However, this protocol did not follow current Drug practice parameters. We report a successful desensitization to MMF in a double heart-kidney transplant reci...

ADV ANCES in surgical techniques and the introduction of the newer. more powerful immunosuppressants have resulted in the successful clinical application of small bowel transplantation. 1-3 This study focused 011 the routine histologic monitoring of small bowel allografts using serial endoscopic biopsies. Histopathologic findings, effectiveness. and the limitations of mucosal biopsies as a moni...

Systemic lupus erythematosus is a prototypic but heterogeneous autoimmune disease. The major clinical symptoms and signs are reviewed, as well as the main immunological abnormalities. Emphasis is put on the role of long-lived autoimmune plasma cells, not affected by current immunosuppressants and biologics, which are responsible for refractoriness and relapses.

We performed in vitro antifungal checkerboard testing on 12 Aspergillus fumigatus clinical isolates (6 transplant recipients and 6 nontransplant patients) with three antifungal agents (amphotericin B, voriconazole, and caspofungin) and three immunosuppressants (FK506, cyclosporine, and rapamycin). We were not able to detect a difference in calcineurin inhibitor antifungal activity against isola...

'l'hl'l'e young male patients dl''Veloped acute glomerulonephr-itis and sel'ious hemoptysis. All three had evidence of antiglomerular basement membmne (anti-GBM) antibodies in their serum and native kidneys. The pulmonary hemorrhages ceased after bilateral nephrectomy and splenectomy accompanied by irregular treatment with steroids and other immunosuppressants. Renal homotransplantation was suc...