AIM The objective of this study was to obtain and compare two-dimensional (2D) and three-dimensional (3D) ultrasonographic images of the urinary bladder in different disease conditions. MATERIALS AND METHODS The present study was conducting on total 10clinical cases of the urinary bladder in dogs. The ultrasound (US) machine used for this study was 3D US machine (Nemio-XG: Toshiba, Japan) hav...

we present a 55-year old male patient who was subjected to whole body skeletal scintigraphy for metastatic work up of urinary bladder cancer. whole body 99mtc-methylene diphosphonate (mdp) skeletal scintigraphy was performed. that revealed no skeletal metastasis in the entire body skeleton and normally visualized left kidney with empty right renal fossa. additionally tracer activity collected i...

UNLABELLED Neuroendocrine carcinoma of the urinary bladder is a rare entity, accounting less then 1% of urinary bladder malignancies. The vast majority of the neuroendocrine carcinoma of the urinary bladder is represented by small cell neuroendocrine carcinoma while just few cases of large cell neuroendocrine carcinoma (LCNEC) have been reported. In this cases report we describe a rare case of ...

BK large conductance voltage- and calcium-activated potassium channels respond to elevations in intracellular calcium and membrane potential depolarization, braking excitability of smooth muscle. BK channels are thought to have a particularly prominent role in urinary bladder smooth muscle function and therefore are candidate targets for overactive bladder therapy. To address the role of the BK...

Many bladder cancers progress to invasion with poor prognosis; new therapeutic methods are needed. We developed a cytotoxic LH-RH analog, AN-152 (AEZS-108) containing doxorubicin (DOX), for targeted therapy of cancers expressing LHRH receptors. We investigated the expression of LH-RH receptors in clinical bladder cancers and in HT-1376, J82, RT-4 and HT-1197 human bladder cancer lines. The effe...

Upper urinary tract urothelial carcinomas (UUTUC) are infrequent and show an occurrence of about 5-10% of all urothelial carcinomas. In this study, we investigated the HER2 status of 171 UUTUC patients with nephroureterectomy. The number of patients is the largest of any HER2 study. All 171 cases were analyzed for both HER2 overexpression using immunohistochemistry and HER2 gene amplification u...

Cancer of the urinary tract in dogs can affect the kidneys, ureters, urinary bladder, prostate, or urethra (see Figure 1). Within the urinary system, the bladder is the location most frequently affected with cancer. Compared to cancer in other locations in the body, bladder cancer is unusual, comprising approximately 2% of all cancers in the dog. With more than 70 million pet dogs in the United...

This study aimed to evaluate the diagnostic and prognostic roles of GATA-binding protein 3 (GATA3) immunohistochemistry in urothelial carcinoma (UC) using a meta-analysis. We investigated GATA3 immunohistochemical expression rates performed subgroup analysis based on tumor site, location, histological subtypes. The overall survival patients with GATA3-positive -negative UC were compared. estima...

Microscopic patterns of thirty-four urothelial tumors of the urinary bladder of water buffaloes from the Marmara and Black Sea Regions of Turkey are here described. All the animals grazed on lands rich in bracken fern. Histological diagnosis was assessed using morphological parameters recently suggested for the urinary bladder tumors of cattle. Papillary carcinoma was the most common neoplastic...

Urinary diversion is a detour of the urinary tract. It may be necessary in different scenarios and can either be continent or incontinent, catheterisable or orthotopic. Pathological situations which may demand a urinary diversion are varied and include anatomical, physiological, congenital and traumatic causes, e.g. urethral stenosis and partial or complete urethral disruption; bladder dysfunct...