نتایج جستجو برای: immunogenic response

تعداد نتایج: 983179  

Alireza Salimi Chirani, Gholamreza Irajian*, Mehrdad Gholami, Mona Moshiri, Reza Falak, Shabnam Razavi,

Background: Pseudomonas aeruginosa, an opportunistic pathogen, is a common cause of healthcare-associated infections in immunocompromised individuals. The rapid emergence of multidrug-resistant strains has made P. aeruginosa infections progressively difficult to treat. In this study we evaluated the effect of a chimeric protein containing a P. aeruginosa PilQ fragment and the PilA disulfide loo...

2015
Tetiana Chudina Andrii Labyntsev Kyrylo Manoilov Denys Kolybo Serhiy Komisarenko

AIM To evaluate the dose-dependent immunogenic properties of poly(lactide-co-glycolide) (PLGA) particles coated with cellobiose as antigen carriers for oral immunization. METHODS Two types of PLGA-cellobiose particles (PLGA-cellobiose-1, ~ 0.8 μm and PLGA-cellobiose-2, ~ 1.2 μm) containing non-toxic recombinant subunit B (SbB) of diphtheria toxin fused with enhanced green fluorescent protein ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Paul B Chapman Dianna Wu Govind Ragupathi Sharon Lu Linda Williams Wen-Jen Hwu Diantha Johnson Philip O Livingston

GD3 ganglioside is an attractive target for immunotherapy of melanoma because it is abundantly expressed on all melanomas but not expressed on most normal tissues. Although GD3 has proven to be one of the least immunogenic gangliosides, our recent studies showed that anti-GD3 antibodies can be induced in patients immunized either with GD3-lactone-KLH (GD3-L-KLH) plus QS-21 adjuvant or with BEC2...

A. Atta A. Raza, G. Muhammad I. Rashid K. Hanif S. Sharif S. U. Rahman

Mastitis is a one of the major diseases of dairy animals. Staphylococcus aureus is the most common microorganism associated with this dairy scourge. Cure rates of mastitis associated with this pathogen are appallingly low. Biofilm is an important virulence factor and immunogenic structure of S. aureus that makes it resistant to phagocytosis and antibiotics. Reports on the efficacy of vaccine pr...

Journal: :Nanoscale 2013
Sharad Gupta Muhammad R Chatni Ayala L N Rao Valentine I Vullev Lihong V Wang Bahman Anvari

We report the first proof-of-principle demonstration of photoacoustic imaging using a contrast agent composed of a plant virus protein shell, which encapsulates indocyanine green (ICG), the only FDA-approved near infrared chromophore. These nano-constructs can provide higher photoacoustic signals than blood in tissue phantoms, and display superior photostability compared to non-encapsulated ICG...

Journal: :The Journal of Experimental Medicine 2007
Iliyan D. Iliev Gianluca Matteoli Maria Rescigno

Recent work suggests that dendritic cells (DCs) in mucosal tissues are "educated" by intestinal epithelial cells (IECs) to suppress inflammation and promote immunological tolerance. After attack by pathogenic microorganisms, however, "non-educated" DCs are recruited from nearby areas, such as the dome of Peyer's patches (PPs) and the blood, to initiate inflammation and the ensuing immune respon...

Journal: :Infection and immunity 1988
P J Baker J R Hiernaux M B Fauntleroy P W Stashak B Prescott J L Cantrell J A Rudbach

Treatment with nontoxic monophosphoryl lipid A increased the magnitude of the immunoglobulin M (IgM) antibody response to type III pneumococcal polysaccharide in young (2- to 4-week-old) mice. This was accompanied by the appearance of significant numbers of IgG1- and IgG3- secreting antibody-forming cells in 4-week-old mice. These findings indicate that monophosphoryl lipid A can be used as an ...

Journal: :Infection and immunity 1991
J R Murphy L Grez L Schlesinger C Ferreccio S Baqar C Muñoz S S Wasserman G Losonsky J G Olson M M Levine

An attenuated Salmonella typhi Ty21a vaccine was administered to 18 infants and toddlers (less than or equal to 24 months old) to determine its safety and immunogenicity. The vaccination (10(9) CFU per dose, three doses) was well tolerated. However, after the vaccination there was no evidence of a humoral or cellular immune response to S. typhi. The vaccine used was known to be immunogenic for ...

2013
Jamie Honeychurch Caroline Dive Timothy M. Illidge

Understanding the immune response to the death of malignant cells is critical for the development of therapeutic strategies designed to stimulate the immune system against cancer. We have developed an inducible caspase-3-mediated death switch model to explore the effects of apoptosis on the host immune system, demonstrating that the synchronous apoptotic demise of established tumors can be immu...

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