We describe a 51-year-old man with Fisher syndrome (FS) and immune thrombocytopenic purpura (ITP) that developed after upper respiratory infection (URI). Laboratory investigations demonstrated immunoglobulin (Ig) G class of anti-GQ1b autoantibody and reduced platelet count with platelet-associated IgG, which spontaneously improved in parallel with neurologic symptoms. Thus the possible associat...

BACKGROUND AND OBJECTIVES Laparoscopic surgical techniques in pregnancy have been accepted and pose minimal risks to the patient and fetus. We present the first reported case of a pregnant woman with immune thrombocytopenia purpura who underwent laparoscopic splenectomy during the second trimester. METHODS AND RESULTS The anesthesia, hematology, and obstetrics services closely followed the pa...

Two sisters suffered from thrombotic thrombocytopenic purpura late in their first pregnancies. HLA typing of the patients and their immediate family members demonstrated no obvious relationship. Hereditary aspects, association with pregnancy, prognosis and management of pregnant women with TTP are discussed.

Immune thrombocytopenic purpura (ITP) has witnessed many changes and updates over the past decade. The definitions of disease subtypes, course and response to treatment have all been standardized recently. Consequent to the lack of an international consensus management guideline, wide variations exist in treatment practice. This is now being addressed to an extent by the much awaited ITP Intern...

Marie Scully, Beverley J. Hunt, Sylvia Benjamin, Ri Liesner, Peter Rose, Flora Peyvandi, Betty Cheung and Samuel J. Machin on behalf of British Committee for Standards in Haematology Department of Haematology, UCLH, London, Department of Haematology, King’s College and Guys &St Thomas’ NHS Trust, London, Department of Haematology, NBSBT and Oxford University Hospitals (OUH) Trust, UK, Departmen...

In this review, we examine the current landscape of health resource utilization and cost-effectiveness data in care patient populations with immune thrombotic thrombocytopenic purpura. We focus on therapeutic (therapeutic plasma exchange, glucocorticoids, rituximab, caplacizumab) diagnostic (ADAMTS13 assay) technologies employed patients rare disease. Health are limited to high-income country c...

thrombotic thrombocytopenic purpura (ttp) is a rare syndrome affecting multiple organs. there is no sufficient evidence regarding the clinical cardiac manifestations of ttp. nonetheless, pathologic cardiac involvement is quite frequent in acute ttp, which is predominantly manifested as myocardial necrosis due to coronary arteriolar microthrombosis. the present case report describes a 43-year-ol...

mediastinal neoplasms are uncommon tumors that can occur at any age but are most common through the fifth decades of life. a wide variety of systemic disorders are associated with 71% of thymomas. the symptoms of these as sociated disorders often lead to the original discovery of the mediastinal tumor. a 35-year-old female with petechia and purpura was admitted to sina hospital of the city of h...

itp is an autoimmune blood disorder in which platelet destruction is mediated by anti-platelet antibodies. the mechanisms of anti-platelet antibodies development are still a little known. the rate of some bacterial or viral agents in cause of itp is well known. recently, some study proposed that h pylori infection may be associated with itp and h pylori eradication can improves platelet counts ...

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