INTRODUCTION Patients suffering from sepsis are currently classified on a clinical basis (i.e., sepsis, severe sepsis, septic shock); however, this clinical classification may not accurately reflect the overall immune status of an individual patient. Our objective was to describe a cohort of patients with sepsis in terms of their measured immune status. METHODS Fifty-two patients with sepsis ...

Background: Immune checkpoint inhibitors (ICIs) have become the standard treatment for patients with advanced non-small cell lung cancer (NSCLC). However, safety and efficacy of ICIs in severe NSCLC poor performance status (PS) are still unclear.

Tuberculosis (TB) disease burden is determined by both Background: infection and progression rate to disease. Progression rate varies by immune status, with prior infection in high burdened settings significantly reducing the progression to disease from subsequent reinfections and completion of successful treatment associated with increased risk of subsequent TB disease. Novel studies of TB vac...

the evaluation of immune status to measles among school children in south of tehran, blood samples were collected from 375 randomly selected school children of elementary schools, junior high schools and high schools. the measurement of measles antibody titer was made by haemagglutination inhibition test, with antibody titer > 1/4 considered as positive. among 375 school children, 6% of them we...

Hyperactivition of an unwanted cellular cascade by the immune-related protein RNase L has been linked to reduced exercise capacity in persons with chronic fatigue syndrome (CFS). This investigation compares exercise capacities of CFS patients with deregulation of the RNase L pathway and CFS patients with normal regulation, while controlling for potentially confounding gender effects. Thirty-fiv...

an evaluation of the prevalence of immune status to rubella was made among 1151 premarital and preconceptional counseled females (17-40 years old) visiting the genetic clinic in tehran. population of tehran, like any other large city, consists of mixtures of various communities and ethnic groups in the country. the method of analysis was rubella haemagglutination inhibition (hl.) test. immunity...

objective: medical students are exposed to various infectious diseases during their clinical training period, including measles and rubella. in iran, to control the outbreaks of measles and rubella a mass vaccination campaign was conducted on 2003. the present investigation evaluates immunity to measles and rubella in a group of babol medical students and determines the prevalence of medical st...

The immune checkpoint inhibitors have significantly modified the therapeutic landscape of advanced non-small cell lung cancer in second-line and, more recently, first-line settings. Because of the superior outcome with pembrolizumab as an upfront strategy, PD-L1 status should now be considered a new reflex biomarker for guiding first-line treatment in patients with advanced non-small cell lung ...