Immune modulation of pancreatic inflammation induces recovery from type 1 diabetes (T1D), but remission was not durable, perhaps because of an inability to sustain the formation and function of new pancreatic β-cells. We have previously shown that Ig-GAD2, carrying GAD 206-220 peptide, induced in hyperglycemic mice immune modulation that was able to control pancreatic inflammation, stimulate β-...

β-glucans are a large class of complex polysaccharides with bioactive properties, including immune modulation. Natural sources these compounds include yeast, oats, barley, mushrooms, and algae. Yeast is abundant in various processes, fermentation, they often discarded as waste products. The production biomolecules from resources growing trend worldwide novel being constantly identified. Yeast-d...

Auto-reactive cells-mediated immune responses are responsible for the current tissue damages during autoimmunity. Accordingly, functional modulation of auto-reactive cells has been a pivotal aim in many of recent studies. In the current study, we investigated the possibility for insertion of regulatory molecules onto auto-reactive cells through exosomal nano-shuttles as a novel approach for phe...