Mechanisms of non-immune haemolytic anemia in burn patients: severely burned patients often present with anemia in the early course of resuscitation, requiring the transfusion of red blood cells. One of the causes is a non-immune haemolytic anemia. On the blood smear, there are morphological abnormalities of the red blood cells such as the presence of spherocytes and schizocytes. This case repo...

Lassa virus (LASV), which causes a viral hemorrhagic fever, inhibits the innate immune response. The exonuclease (ExoN) domain of its nucleoprotein (NP) is implicated in the suppression of retinoic acid-inducible gene I (RIG-I) signaling. We show here that a LASV in which ExoN function has been abolished strongly activates innate immunity and that this effect is dependent on RIG-I signaling. Th...

Mycobacterium tuberculosis (MTB) is one of the most successful pathogens in human history and remains a global health challenge. MTB has evolved a plethora of strategies to evade the immune response sufficiently to survive within the macrophage in a bacterial-immunological equilibrium, yet causes sufficient immunopathology to facilitate its transmission. This review highlights MTB as the driver...

Golden pompano (Trachinotus ovatus) has become an economically important fish in China the past decade. However, Cryptocaryon irritans, a parasitic ciliate, causes considerable economic losses mariculture of T. ovatus. To characterize pathogenesis C. irritans ovatus, pathological properties, immune-related enzyme activity and expression NEMO gene was analysed. The results from histological sect...

In order to understand AIDS (acquired immunodeficiency syndrome), we need to discuss two major biological phenomena: the virus that causes AIDS, known as human immunodeficiency virus, HIV, and the cells in the immune system that are by HIV. Only when both are described does the disease begin to make sense. We begin by extending our earlier description of how the immune system works and then exa...

Borna disease virus (BDV) infection represents an excellent model system to study immunopathological mechanisms based on a T cell-mediated immune reaction in the central nervous system. The single-stranded RNA Borna disease virus, a member of Bornaviridae in the order of Mononegavirale, lacks cytopathogenicity both in vitro and in vivo. After experimental infection BDV causes a persistent infec...

Measles causes a profound immune suppression which is responsible for the high morbidity and mortality induced by secondary infections. Dendritic cells (DC) are professional antigen-presenting cells required for initiation of primary immune responses. To determine whether infection of DC by measles virus (MV) may play a role in virus-induced suppression of cell-mediated immunity, we examined th...

4. Polysaccharide vaccine (PPV23), used in subjects older than 2 years since decades ago, includes a greater number of serotypes (23), but it does not generate immune memory, antibody levels decrease with time, causes an immune tolerance phenomenon, have no effect on nasopharyngeal colonization and has not shown vaccine effectiveness in these risk groups in the United Kingdom despite a 75% of v...

The pathological changes involved in the immunological lung diseases of the bronchiolar region are reviewed. Next, the possibility that BOOP and DPB, two diseases whose causes are presently unknown, are caused by immune responses, is discussed.

Leptospiral lipopolysaccharide (L-LPS) has shown potency in activating toll-like receptor 2 (TLR2) in pig fibroblasts (PEFs_NCC1), and causes the expression of proinflammatory cytokines. However, the stimulation by L-LPS was weak eliciting the function of TLR2 sufficiently in pig innate immunity responses during Leptospira infection. In this study, the immune response of pig embryonic fibroblas...