Early immature T cell acute lymphoblastic leukemias (T-ALLs) account for ~5-10% of pediatric T-ALLs and are associated with poor prognosis. However, the genetic defects that drive the biology of these tumors remain largely unknown. In this study, analysis of microarray gene expression signatures in adult T-ALL demonstrated a high prevalence of early immature leukemias and revealed a close relat...

To complete their maturation and to participate in the humoral immune response, immature B cells that leave the bone marrow are targeted to specific areas in the spleen, where they differentiate into mature cells. Previously, we showed that immature B cells actively down-regulate their integrin-mediated migration to lymph nodes or sites of inflammation, enabling their targeting to the spleen to...

the life history, behavior and morphology of the immature stages of enochrus quadripunctatus herbst from iran are studied. the results of the work on the life history and behavior of this species in the immature stages and as newly-emerged adults have been presented as part i. the morphology of the egg cases, larvae, pupae, and the male genitalia of the adult is covered in the present work. mea...

Recently, St. Anthony's Medical Center Laboratory (SAMC) in St. Louis, Missouri, installed a new automated hematology analyzer, the Sysmex XE-2100. The XE-2100 has an additional differential parameter, the immature granulocyte (IG) parameter. Prior to implementation, the IG parameter was evaluated by comparison to the manual immature granulocyte count. Immature granulocytes counted manually, as...

The products of the Rag1 and Rag2 genes drive genomic V(D)J rearrangements that assemble functional immunoglobulin and T cell antigen receptor genes. Expression of the Rag genes has been thought to be limited to developmentally immature lymphocyte populations that in normal adult animals are primarily restricted to the bone marrow and thymus. Abundant RAG1 and RAG2 protein and messenger RNA was...

0022-1031/$ see front matter 2009 Elsevier Inc. A doi:10.1016/j.jesp.2009.03.009 * Corresponding author. E-mail address: [email protected] (D.M. Op Participants are not always as diligent in reading and following instructions as experimenters would like them to be. When participants fail to follow instructions, this increases noise and decreases the validity of their data. This paper prese...

OBJECTIVES To integrate an Internet-based medical chart (IMC) system into a pharmacotherapy course to facilitate evaluation and feedback processes, foster development of written documentation skills, and prepare pharmacy students for future changes in electronic medical documentation systems. DESIGN An IMC system was introduced into a pharmacotherapy course for third-professional year pharmac...

Cells of Paramecium in the sexually immature period of the clonal life cycle contain a protein called immaturin, which represses mating activity when injected into sexually mature cells. The amount of immaturin at various stages of the immaturity period was examined by injecting cytoplasm from immature cells of one wild-type and two early mature mutant clones into mature cells of wild-type. The...

Three distinct immature T-cell acute lymphoblastic leukemia entities have been described including cases that express an early T-cell precursor immunophenotype or expression profile, immature MEF2C-dysregulated T-cell acute lymphoblastic leukemia cluster cases based on gene expression analysis (immature cluster) and cases that retain non-rearranged TRG@ loci. Early T-cell precursor acute lympho...