The I1 subtype of imidazoline receptors (I1R) is a plasma membrane protein that is involved in diverse physiological functions. Available radioligands used so far to characterize the I(1)R were able to bind with similar affinities to alpha2-adrenergic receptors (alpha2-ARs) and to I1R. This feature was a major drawback for an adequate characterization of this receptor subtype. New imidazoline a...

Zolpidem, an imidazoline nonbenzodiazepine sedative drug, is used widely. Initial reports showed minimal abuse potential. However, multiple reports have appeared of dose escalation and abuse. Subjective effects of high-dose zolpidem are not known. In light of accumulating evidence of abuse potential, we hereby report a case of high-dose dependence and a review of relevant literature. A 33-year-...

The asymmetric unit of the title salt, CH(6)N(3) (+)·C(2)H(8)N(+)·C(10)H(6)O(6)S(2) (2-), consists of one dimethyl-ammonium cation, one guanidinium cation, and two half naphthalene-1,5-disulfonate anions, which lie on inversion centers. N-H⋯O hydrogen bonds link the cations and anions into layers parallel to the ab plane. The layers have a sandwich-like structure, with the sulfonate groups and ...

In the title compound, CH(6)N(3) (+)·C(16)H(31)O(4)S(2) (-) [systematic name: guanidinium 2-(tetra-deca-noylsulfan-yl)ethane-sulfon-ate], each 2-(myristoyl-thio)-ethane-sulfonate ion displays hydrogen bonding to three guanidinium counter-ions, which themselves display hydrogen bonding to two symmetry-related 2-(myristoylthio)ethanesulfonate ions. Thus each cation forms six N-H⋯O bonds to neighb...

A combination of electrochemical measurement and interface analysis have been applied to characterise the interaction OMID, an exemplar imidazoline-based corrosion inhibitor, with carbon steel in 1 M hydrochloric acid. Corrosion inhibition efficiency data indicate that excellent performance is achieved well below critical micelle concentration. High resolution X-ray photoelectron spectra demons...

The reaction of the ligand Et4todit (4,5,6,7-Tetrathiocino-[1,2-b:3,4-b']diimidazolyl-1,3,8,10-tetraethyl-2,9-dithione) with gold complexes leads to the dinuclear gold(I) complexes [{Au(C6F5)}2(Et4todit)] and [Au(Et4todit)]2(OTf)2, which do not contain any gold-gold interactions, or to the gold(III) derivative [{Au(C6F5)3}2(Et4todit)]. The crystal structures have been established by X-ray diffr...

2-Mercapto-1-methyl-imidazoline (N(2)C(4)H(6)S) is converted at room temperature into 2-bromo-1-methyl-imidazole (N(2)C(4)H(5)Br) in presence of copper(I) bromide in acetonitrile-chloroform mixture via extrusion of sulfur as sulfate and oxidation of Cu(I) into Cu(II). 2-Bromo-1-methyl-imidazole was isolated as its self assembled tetranuclear Cu(II) cluster, [Cu(4)(η(1)-N-(N(2)C(4)H(5)Br)(4)(μ(4...

The synthesis, single crystal X-ray structure and activity in olefin metathesis of novel anionic tungsten imido alkylidene complexes [1,3-bis-(2,4,6-trimethylphenyl)imidazolinium](+) [W(N-2,6-iPr2C6H3)(CHCMe2Ph)(2,5-Me2Pyr)2Cl](-), [1,3-bis-(2,4,6-trimethylphenyl)imidazolinium](+) [W(N-2,6-iPr2C6H3)(CHCMe2Ph)(2,5Me2Pyr)2(OC6F5)](-), and [1,3-bis-(2,6-diisopropylphenyl)imidazolinium](+) [W(N-2,6...

The crystal structure of the title compound, C(12)H(17)N(3)O(2) (+)·ClO(4) (-), consists of 4,4,5,5-tetra-methyl-2-(4-pyridinio)imidazoline-1-oxyl-3-oxide radical cations and perchlorate anions. Both the cation and the Cl atom of the anion are located on the same twofold rotation axis, and the crystal structure shows the average structure for the radical cation. The five-membered ring assumes a...